Blocking of SGLT2 to Eliminate NADPH-Induced Oxidative Stress in Lenses of Animals with Fructose-Induced Diabetes Mellitus.
Animals
Cataract
Diabetes Mellitus
Fructose
/ adverse effects
Metformin
/ pharmacology
NADP
/ metabolism
NADPH Oxidases
/ metabolism
Oxidative Stress
Reactive Oxygen Species
/ metabolism
Receptor for Advanced Glycation End Products
/ metabolism
Resveratrol
/ pharmacology
Sodium-Glucose Transporter 2
/ metabolism
NADPH oxidase
cataract
glucose transporter
resveratrol
type 2 diabetes mellitus
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
27 Jun 2022
27 Jun 2022
Historique:
received:
25
05
2022
revised:
20
06
2022
accepted:
24
06
2022
entrez:
9
7
2022
pubmed:
10
7
2022
medline:
14
7
2022
Statut:
epublish
Résumé
Chronic hyperglycemia triggers an abnormal rise in reactive oxygen species (ROS) that leads to blindness in patients with diabetes mellitus (DM) and cataracts. In this study, the effects of dapagliflozin, metformin and resveratrol on ROS production were investigated in lens epithelial cells (LECs) of animals with fructose-induced DM. LECs were isolated from patients without DM, or with DM devoid of diabetic retinopathy. Animals were treated with 10% fructose for 8 weeks to induce DM, which was verified by monitoring blood pressure and serum parameters. For drug treatments, 1.2 mg/day of dapagliflozin was given for 2 weeks, 500 mg/kg/day of metformin was given, and 10 mg/kg/day of resveratrol was given. Dihydroethidium was used to stain endogenous O
Identifiants
pubmed: 35806147
pii: ijms23137142
doi: 10.3390/ijms23137142
pmc: PMC9266761
pii:
doi:
Substances chimiques
Reactive Oxygen Species
0
Receptor for Advanced Glycation End Products
0
Sodium-Glucose Transporter 2
0
Fructose
30237-26-4
NADP
53-59-8
Metformin
9100L32L2N
NADPH Oxidases
EC 1.6.3.-
Resveratrol
Q369O8926L
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Kaohsiung Veterans General Hospital
ID : KSVGH110-141
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