Neurogranin and Neurofilament Light Chain as Preclinical Biomarkers in Scrapie.
biomarkers
neurodegeneration
neurofilament light chain
neurogranin
prion
prion diseases
scrapie
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
28 Jun 2022
28 Jun 2022
Historique:
received:
31
05
2022
revised:
19
06
2022
accepted:
27
06
2022
entrez:
9
7
2022
pubmed:
10
7
2022
medline:
14
7
2022
Statut:
epublish
Résumé
Prion diseases are diagnosed in the symptomatic stage, when the neuronal damage is spread throughout the central nervous system (CNS). The assessment of biological features that allow the detection of asymptomatic cases is needed, and, in this context, scrapie, where pre-symptomatic infected animals can be detected through rectal biopsy, becomes a good study model. Neurogranin (Ng) and neurofilament light chain (NfL) are proteins that reflect synaptic and axonal damage and have been studied as cerebrospinal fluid (CSF) biomarkers in different neurodegenerative disorders. In this study, we evaluated Ng and NfL both at the protein and transcript levels in the CNS of preclinical and clinical scrapie-affected sheep compared with healthy controls and assessed their levels in ovine CSF. The correlation between these proteins and the main neuropathological events in prion diseases, PrP
Identifiants
pubmed: 35806183
pii: ijms23137182
doi: 10.3390/ijms23137182
pmc: PMC9266981
pii:
doi:
Substances chimiques
Biomarkers
0
Neurofilament Proteins
0
Neurogranin
132654-77-4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : MINISTERIO DE CIENCIA, INNOVACIÓN Y UNIVERSIDADES
ID : RTI2018-098711-B-I00
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