Repurposing the cardiac glycoside digoxin to stimulate myelin regeneration in chemically-induced and immune-mediated mouse models of multiple sclerosis.
Animals
Cardiac Glycosides
/ adverse effects
Cell Differentiation
Cuprizone
Demyelinating Diseases
/ chemically induced
Digoxin
/ adverse effects
Disease Models, Animal
Drug Repositioning
Female
Mice
Mice, Inbred C57BL
Multiple Sclerosis
/ drug therapy
Myelin Sheath
/ physiology
Oligodendroglia
/ physiology
digoxin
immune tolerance
multiple sclerosis
myelin regeneration
oligodendrocyte
Journal
Glia
ISSN: 1098-1136
Titre abrégé: Glia
Pays: United States
ID NLM: 8806785
Informations de publication
Date de publication:
10 2022
10 2022
Historique:
revised:
07
06
2022
received:
25
08
2021
accepted:
14
06
2022
pubmed:
10
7
2022
medline:
17
8
2022
entrez:
9
7
2022
Statut:
ppublish
Résumé
Multiple sclerosis (MS) is a central nervous system (CNS) autoimmune disease characterized by inflammation, demyelination, and neurodegeneration. The ideal MS therapy would both specifically inhibit the underlying autoimmune response and promote repair/regeneration of myelin as well as maintenance of axonal integrity. Currently approved MS therapies consist of non-specific immunosuppressive molecules/antibodies which block activation or CNS homing of autoreactive T cells, but there are no approved therapies for stimulation of remyelination nor maintenance of axonal integrity. In an effort to repurpose an FDA-approved medication for myelin repair, we chose to examine the effectiveness of digoxin, a cardiac glycoside (Na
Identifiants
pubmed: 35809238
doi: 10.1002/glia.24231
pmc: PMC9378523
mid: NIHMS1817265
doi:
Substances chimiques
Cardiac Glycosides
0
Cuprizone
5N16U7E0AO
Digoxin
73K4184T59
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1950-1970Subventions
Organisme : NINDS NIH HHS
ID : R01 NS034939
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS099334
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI142059
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI151438
Pays : United States
Informations de copyright
© 2022 The Authors. GLIA published by Wiley Periodicals LLC.
Références
Bioinformatics. 2015 Jan 15;31(2):166-9
pubmed: 25260700
Ann Neurol. 2009 Mar;65(3):239-48
pubmed: 19334069
Annu Rev Biomed Eng. 2016 Jul 11;18:181-205
pubmed: 26928211
Nanomedicine. 2017 Jan;13(1):191-200
pubmed: 27720992
Brain. 1988 Jun;111 ( Pt 3):675-94
pubmed: 3382916
J Clin Invest. 2017 Sep 1;127(9):3271-3280
pubmed: 28862639
Nat Med. 2014 Aug;20(8):954-960
pubmed: 24997607
Neuron. 2011 Sep 8;71(5):799-811
pubmed: 21903074
Nanomedicine. 2019 Jun;18:282-291
pubmed: 30352312
J Vis Exp. 2015 Mar 26;(97):
pubmed: 25867716
Bioinformatics. 2016 Oct 1;32(19):3047-8
pubmed: 27312411
Nat Commun. 2019 Aug 29;10(1):3887
pubmed: 31467299
J Neurosci. 2002 Apr 1;22(7):2451-9
pubmed: 11923409
Brain. 2020 Apr 1;143(4):1127-1142
pubmed: 32293668
Ann Neurol. 1989 Feb;25(2):159-65
pubmed: 2537596
Cold Spring Harb Perspect Biol. 2015 Jun 22;8(1):a020479
pubmed: 26101081
Neuroscientist. 2019 Aug;25(4):334-343
pubmed: 30122106
Glia. 2022 Oct;70(10):1950-1970
pubmed: 35809238
Nature. 2017 Jan 26;541(7638):481-487
pubmed: 28099414
Nat Rev Neurol. 2019 Jan;15(1):53-58
pubmed: 30315270
BMC Bioinformatics. 2015 May 22;16:169
pubmed: 25994840
Front Cell Neurosci. 2020 Oct 27;14:599717
pubmed: 33192332
Cell. 2010 Mar 19;140(6):918-34
pubmed: 20303880
J Gen Physiol. 1967 Mar;50(4):893-916
pubmed: 4291916
Genome Biol. 2014;15(12):550
pubmed: 25516281
Gastroenterology. 2020 May;158(6):1667-1681.e12
pubmed: 32032584
Nat Chem Biol. 2010 Jun;6(6):411-7
pubmed: 20436487
Trends Neurosci. 2019 Apr;42(4):263-277
pubmed: 30770136
PLoS One. 2017 Aug 8;12(8):e0182372
pubmed: 28792512
Nature. 2015 Jun 11;522(7555):216-20
pubmed: 25896324
J Neurochem. 2019 Oct;151(2):139-165
pubmed: 31318452
PLoS One. 2014 Sep 23;9(9):e107649
pubmed: 25247590
Gastroenterology. 2021 Jul;161(1):66-80.e8
pubmed: 33722583
Trends Mol Med. 2010 Aug;16(8):379-86
pubmed: 20591737
Neurodegener Dis Manag. 2020 Dec;10(6):409-423
pubmed: 33054615
BMC Neurosci. 2016 Apr 22;17:16
pubmed: 27103572
Nucleic Acids Res. 2001 May 1;29(9):e45
pubmed: 11328886
ACS Nano. 2014 Mar 25;8(3):2148-60
pubmed: 24559284
Bioinformatics. 2013 Jan 1;29(1):15-21
pubmed: 23104886
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2014 May-Jun;6(3):298-315
pubmed: 24616452
Nature. 2013 Oct 17;502(7471):327-332
pubmed: 24107995
Nat Immunol. 2007 Sep;8(9):913-9
pubmed: 17712344
J Autoimmun. 2018 May;89:112-124
pubmed: 29258717
Discov Med. 2013 Aug;16(86):53-63
pubmed: 23911232
Nat Biotechnol. 2012 Dec;30(12):1217-24
pubmed: 23159881
Nat Cell Biol. 2012 Aug;14(8):859-64
pubmed: 22750943
Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):1755-60
pubmed: 25624492
Sci Transl Med. 2013 Jun 5;5(188):188ra75
pubmed: 23740901
J Neurosci. 2015 Oct 14;35(41):14031-41
pubmed: 26468203
Adv Drug Deliv Rev. 2017 May 15;114:240-255
pubmed: 28414079
Neuron. 2020 Jan 22;105(2):293-309.e5
pubmed: 31901304
J Immunol. 2013 Dec 1;191(11):5341-6
pubmed: 24244028
Nat Commun. 2019 Apr 3;10(1):1523
pubmed: 30944313
Neurosci Biobehav Rev. 2014 Nov;47:485-505
pubmed: 25445182
J Neurosci. 2016 Apr 27;36(17):4698-707
pubmed: 27122029
Proc Natl Acad Sci U S A. 2016 May 3;113(18):5059-64
pubmed: 27091976
Cold Spring Harb Protoc. 2013 Sep 01;2013(9):854-68
pubmed: 24003195
Sci Rep. 2020 Feb 11;10(1):1936
pubmed: 32041968
Ann Neurol. 1990 Oct;28(4):582-4
pubmed: 2252371
J Neurosci. 2011 Jan 12;31(2):538-48
pubmed: 21228163
Methods Mol Biol. 2016;1304:145-60
pubmed: 25005074