Acetyl-CoA-Carboxylase 1-mediated de novo fatty acid synthesis sustains Lgr5
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
09 07 2022
09 07 2022
Historique:
received:
16
07
2020
accepted:
13
06
2022
entrez:
9
7
2022
pubmed:
10
7
2022
medline:
14
7
2022
Statut:
epublish
Résumé
Basic processes of the fatty acid metabolism have an important impact on the function of intestinal epithelial cells (IEC). However, while the role of cellular fatty acid oxidation is well appreciated, it is not clear how de novo fatty acid synthesis (FAS) influences the biology of IECs. We report here that interfering with de novo FAS by deletion of the enzyme Acetyl-CoA-Carboxylase (ACC)1 in IECs results in the loss of epithelial crypt structures and a specific decline in Lgr5
Identifiants
pubmed: 35810180
doi: 10.1038/s41467-022-31725-2
pii: 10.1038/s41467-022-31725-2
pmc: PMC9271096
doi:
Substances chimiques
Fatty Acids
0
Acetyl Coenzyme A
72-89-9
Acetyl-CoA Carboxylase
EC 6.4.1.2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3998Informations de copyright
© 2022. The Author(s).
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