Genome-wide identification of circular RNAs in adult Schistosoma japonicum.
Circular RNAs
Gene regulation
Genome-wide
Schistosoma japonicum
Schistosomiasis
microRNAs
Journal
International journal for parasitology
ISSN: 1879-0135
Titre abrégé: Int J Parasitol
Pays: England
ID NLM: 0314024
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
received:
02
03
2022
revised:
22
05
2022
accepted:
24
05
2022
pubmed:
11
7
2022
medline:
28
9
2022
entrez:
10
7
2022
Statut:
ppublish
Résumé
Circular RNAs (circRNAs) are a class of novel, widespread, covalently closed RNAs that have played an essential role in animal gene regulation. To systematically explore circRNAs in the blood fluke Schistosoma japonicum, we performed RNA sequencing and bioinformatics analysis, and found that hundreds of circRNAs showed gender-associated expression. Among these identified circRNAs, more than 77.54% and 74.73% were putatively derived from the exon region of the genome and some circRNAs showed gender-associated expressions. The functional prediction of circRNAs (circ_003826 and circ_004690) showed potential binding sites and possibly acted as the sponge to regulate microRNAs (miRNAs) sja-miR-1, sja-miR-133 and sja-miR-3504. Altogether, these findings demonstrated that S. japonicum also contains circRNAs, which may have potential regulatory roles during schistosome development.
Identifiants
pubmed: 35810786
pii: S0020-7519(22)00099-6
doi: 10.1016/j.ijpara.2022.05.003
pii:
doi:
Substances chimiques
MicroRNAs
0
RNA, Circular
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
629-636Informations de copyright
Copyright © 2022 Australian Society for Parasitology. Published by Elsevier Ltd. All rights reserved.