G protein-coupled receptor signaling: transducers and effectors.
G protein
G protein-coupled receptor
GPCR kinase
effector
transducer
β-arrestin
Journal
American journal of physiology. Cell physiology
ISSN: 1522-1563
Titre abrégé: Am J Physiol Cell Physiol
Pays: United States
ID NLM: 100901225
Informations de publication
Date de publication:
01 09 2022
01 09 2022
Historique:
pubmed:
12
7
2022
medline:
9
9
2022
entrez:
11
7
2022
Statut:
ppublish
Résumé
G protein-coupled receptors (GPCRs) are of considerable interest due to their importance in a wide range of physiological functions and in a large number of Food and Drug Administration (FDA)-approved drugs as therapeutic entities. With continued study of their function and mechanism of action, there is a greater understanding of how effector molecules interact with a receptor to initiate downstream effector signaling. This review aims to explore the signaling pathways, dynamic structures, and physiological relevance in the cardiovascular system of the three most important GPCR signaling effectors: heterotrimeric G proteins, GPCR kinases (GRKs), and β-arrestins. We will first summarize their prominent roles in GPCR pharmacology before transitioning into less well-explored areas. As new technologies are developed and applied to studying GPCR structure and their downstream effectors, there is increasing appreciation for the elegance of the regulatory mechanisms that mediate intracellular signaling and function.
Identifiants
pubmed: 35816644
doi: 10.1152/ajpcell.00210.2022
pmc: PMC9448338
doi:
Substances chimiques
Arrestins
0
Receptors, G-Protein-Coupled
0
beta-Arrestins
0
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
C731-C748Références
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