Praziquantel Reduces Maternal Mortality and Offspring Morbidity by Enhancing Anti-Helminthic Immune Responses.
Praziquantel (PZQ)
Schistosomiasis
anthelminthic
fetomaternal cross talk
transgenerational immune priming
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
17
02
2022
accepted:
30
05
2022
entrez:
14
7
2022
pubmed:
15
7
2022
medline:
16
7
2022
Statut:
epublish
Résumé
Alongside the wide distribution throughout sub Saharan Africa of schistosomiasis, the morbidity associated with this chronic parasitic disease in endemic regions is often coupled with infection-driven immunomodulatory processes which modify inflammatory responses. Early life parasite exposure is theorized to drive immune tolerance towards cognate infection as well as bystander immune responses, beginning with
Identifiants
pubmed: 35833137
doi: 10.3389/fimmu.2022.878029
pmc: PMC9272909
doi:
Substances chimiques
Anthelmintics
0
Cytokines
0
Praziquantel
6490C9U457
Mebendazole
81G6I5V05I
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
878029Informations de copyright
Copyright © 2022 Lacorcia, Kugyelka, Spechtenhauser, Prodjinotho, Hamway, Spangenberg and da Costa.
Déclaration de conflit d'intérêts
TS is an employee of Ares Trading SA, an affiliate of Merck KGaA, Darmstadt, Germany. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The authors declare that this study received funding from Merck KGaA, Darmstadt, Germany. The funder was involved in the design of the study, data interpretation and preparation of the manuscript.
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