Glucose-1,6-Bisphosphate, a Key Metabolic Regulator, Is Synthesized by a Distinct Family of α-Phosphohexomutases Widely Distributed in Prokaryotes.
carbon metabolism
glucose-1,6-bisphosphate
glycolysis
phosphoglucomutase
Journal
mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231
Informations de publication
Date de publication:
30 08 2022
30 08 2022
Historique:
pubmed:
21
7
2022
medline:
3
9
2022
entrez:
20
7
2022
Statut:
ppublish
Résumé
The reactions of α-d-phosphohexomutases (αPHM) are ubiquitous, key to primary metabolism, and essential for several processes in all domains of life. The functionality of these enzymes relies on an initial phosphorylation step which requires the presence of α-d-glucose-1,6-bisphosphate (Glc-1,6-BP). While well investigated in vertebrates, the origin of this activator compound in bacteria is unknown. Here we show that the Slr1334 protein from the unicellular cyanobacterium
Identifiants
pubmed: 35856562
doi: 10.1128/mbio.01469-22
pmc: PMC9426568
doi:
Substances chimiques
Glucose-6-Phosphate
56-73-5
glucose-1,6-bisphosphate
DRX17R6AM2
Phosphoglucomutase
EC 5.4.2.2
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0146922Références
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