Mechanisms of central brain atrophy in multiple sclerosis.
MS lesions
brain atrophy
lesion expansion
slow-burning inflammation
Journal
Multiple sclerosis (Houndmills, Basingstoke, England)
ISSN: 1477-0970
Titre abrégé: Mult Scler
Pays: England
ID NLM: 9509185
Informations de publication
Date de publication:
Nov 2022
Nov 2022
Historique:
pubmed:
22
7
2022
medline:
19
10
2022
entrez:
21
7
2022
Statut:
ppublish
Résumé
Change in ventricular volume has been suggested as surrogate measure of central brain atrophy (CBA) applicable to the everyday management of multiple sclerosis (MS) patients. We investigated the contribution of inflammatory activity (including the severity of lesional tissue damage) to CBA. Fifty patients with relapsing-remitting multiple sclerosis (RRMS) were enrolled. Lesional activity during 4 years of follow-up was analysed using custom-build software, which segmented expanding part of the chronic lesions, new confluent lesions and new free-standing lesions. The degree of lesional tissue damage was assessed by change in mean diffusivity (MD). Volumetric change of lateral ventricles was used to measure CBA. During follow-up, ventricles expanded on average by 12.6% ± 13.7% (mean ± CBA is almost entirely explained by the combination of the volume and severity of lesional activity. The expansion of chronic lesions plays a central role in this process.
Sections du résumé
BACKGROUND
Change in ventricular volume has been suggested as surrogate measure of central brain atrophy (CBA) applicable to the everyday management of multiple sclerosis (MS) patients.
OBJECTIVES
We investigated the contribution of inflammatory activity (including the severity of lesional tissue damage) to CBA.
METHODS
Fifty patients with relapsing-remitting multiple sclerosis (RRMS) were enrolled. Lesional activity during 4 years of follow-up was analysed using custom-build software, which segmented expanding part of the chronic lesions, new confluent lesions and new free-standing lesions. The degree of lesional tissue damage was assessed by change in mean diffusivity (MD). Volumetric change of lateral ventricles was used to measure CBA.
RESULTS
During follow-up, ventricles expanded on average by 12.6% ± 13.7% (mean ±
DISCUSSION
CBA is almost entirely explained by the combination of the volume and severity of lesional activity. The expansion of chronic lesions plays a central role in this process.
Identifiants
pubmed: 35861244
doi: 10.1177/13524585221111684
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM