Rhesus rotavirus receptor-binding site affects high mobility group box 1 release, altering the pathogenesis of experimental biliary atresia.
Journal
Hepatology communications
ISSN: 2471-254X
Titre abrégé: Hepatol Commun
Pays: United States
ID NLM: 101695860
Informations de publication
Date de publication:
10 2022
10 2022
Historique:
revised:
26
05
2022
received:
15
04
2022
accepted:
30
05
2022
pubmed:
23
7
2022
medline:
28
9
2022
entrez:
22
7
2022
Statut:
ppublish
Résumé
Biliary atresia (BA) is a neonatal inflammatory cholangiopathy that requires surgical intervention by Kasai portoenterostomy to restore biliary drainage. Even with successful portoenterostomy, most patients diagnosed with BA progress to end-stage liver disease, necessitating a liver transplantation for survival. In the murine model of BA, rhesus rotavirus (RRV) infection of neonatal mice induces an inflammatory obstructive cholangiopathy that parallels human BA. The model is triggered by RRV viral protein (VP)4 binding to cholangiocyte cell-surface proteins. High mobility group box 1 (HMGB1) protein is a danger-associated molecular pattern that when released extracellularly moderates innate and adaptive immune response. In this study, we investigated how mutations in three RRV VP4-binding sites, RRV
Identifiants
pubmed: 35866580
doi: 10.1002/hep4.2024
pmc: PMC9512450
doi:
Substances chimiques
Integrin alpha2beta1
0
Viral Proteins
0
N-Acetylneuraminic Acid
GZP2782OP0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
2702-2714Subventions
Organisme : NIAID NIH HHS
ID : R21 AI097936
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK078392
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES006096
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA122346
Pays : United States
Organisme : NHLBI NIH HHS
ID : U54 HL127624
Pays : United States
Informations de copyright
© 2022 The Authors. Hepatology Communications published by Wiley Periodicals LLC on behalf of American Association for the Study of Liver Diseases.
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