Phloretin exhibits potential food-drug interactions by inhibiting human UDP-glucuronosyltransferases in vitro.

Food-Drug Interactions Glucuronosyltransferase / metabolism Humans Kinetics Phloretin / pharmacology Uridine Diphosphate
Apple polyphenols Enzymes inhibition Food-drug interactions IVIVE Phloretin UGTs

Journal

Toxicology in vitro : an international journal published in association with BIBRA
ISSN: 1879-3177
Titre abrégé: Toxicol In Vitro
Pays: England
ID NLM: 8712158

Informations de publication

Date de publication:
Oct 2022
Historique:
received: 20 05 2022
revised: 11 07 2022
accepted: 14 07 2022
pubmed: 23 7 2022
medline: 8 9 2022
entrez: 22 7 2022
Statut: ppublish

Résumé

Phloretin is a well-known apple polyphenol possessing a wide variety of biological effects and has been widely used in many fields. However, it's unclear whether phloretin has an effect on the activity of human UGT enzymes. Our study indicated that phloretin inhibited human UGTs on a broad spectrum. Further kinetic analysis revealed that phloretin inhibited UGT1A1, 1A6, 1A9, 2B7, and 2B15 in a noncompetitive manner, with calculated K

Identifiants

DOI: 10.1016/j.tiv.2022.105447 PMID: 35868516
pubmed: 35868516
pii: S0887-2333(22)00145-X
doi: 10.1016/j.tiv.2022.105447
pii:
doi:

Substances chimiques

Uridine Diphosphate 58-98-0
Glucuronosyltransferase EC 2.4.1.17
Phloretin S5J5OE47MK

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

105447

Informations de copyright

Copyright © 2022 The Authors. Published by Elsevier Ltd.. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that there is no conflict of interests regarding the publication of this article.

Auteurs

Jinqian Chen (J)

Departments of Pharmacy, NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University Chu Hsien-I Memorial Hospital, Tianjin 300134, PR China.

Hao Zhang (H)

Tianjin Key Laboratory of Animal and Plant Resistance, College of Life Sciences, Tianjin Normal University, Tianjin 300387, PR China.

Xia Hu (X)

Department of Agriculture Insect, Institute of Plant Protection, Tianjin Academy of Agricultural Sciences, Tianjin 300384, PR China.

Mengyuan Xu (M)

Tianjin Key Laboratory of Animal and Plant Resistance, College of Life Sciences, Tianjin Normal University, Tianjin 300387, PR China.

Yanjun Su (Y)

Department of Lung Cancer, Tianjin Lung Cancer Center, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, PR China.

Chunze Zhang (C)

Department of Colorectal Surgery, Tianjin Union Medical Center, Tianjin 300121, PR China.

Yuan Yue (Y)

Tianjin Key Laboratory of Animal and Plant Resistance, College of Life Sciences, Tianjin Normal University, Tianjin 300387, PR China.

Xiaomin Zhang (X)

Tianjin Key Laboratory of Animal and Plant Resistance, College of Life Sciences, Tianjin Normal University, Tianjin 300387, PR China.

Xinyu Wang (X)

Tianjin Key Laboratory of Animal and Plant Resistance, College of Life Sciences, Tianjin Normal University, Tianjin 300387, PR China.

Wei Cui (W)

School of Mathematical Sciences and LPMC, Nankai University, Tianjin 300070, PR China.

Zhenyu Zhao (Z)

Departments of Pharmacy, NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of Metabolic Diseases, Tianjin Medical University Chu Hsien-I Memorial Hospital, Tianjin 300134, PR China. Electronic address: zhaozhenyu0858@163.com.

Xichuan Li (X)

Tianjin Key Laboratory of Animal and Plant Resistance, College of Life Sciences, Tianjin Normal University, Tianjin 300387, PR China. Electronic address: xichuanli@tjnu.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Interactions médicamenteuses › Interactions aliments-médicaments › Phloretin exhibits potential food-drug...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Glycosyltransferase › Hexosyltransferases › Glucuronosyltransferase › Phloretin exhibits potential food-drug...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Phloretin exhibits potential food-drug...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Cinétique › Phloretin exhibits potential food-drug...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrannes › Phlorétine › Phloretin exhibits potential food-drug...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › Ribonucléotides › Nucléotides uridyliques › Uridine diphosphate › Phloretin exhibits potential food-drug...