A network of cytosolic (co)chaperones promotes the biogenesis of mitochondrial signal-anchored outer membrane proteins.
Cytosol
/ metabolism
HSP70 Heat-Shock Proteins
/ metabolism
Mitochondrial Membrane Transport Proteins
/ metabolism
Mitochondrial Precursor Protein Import Complex Proteins
Mitochondrial Proteins
/ genetics
Molecular Chaperones
/ metabolism
Peptides
/ metabolism
Saccharomyces cerevisiae
/ genetics
Saccharomyces cerevisiae Proteins
/ metabolism
S. cerevisiae
biochemistry
chaperones
chemical biology
mitochondria
outer membrane
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
25 07 2022
25 07 2022
Historique:
received:
08
02
2022
accepted:
25
07
2022
pubmed:
26
7
2022
medline:
10
8
2022
entrez:
25
7
2022
Statut:
epublish
Résumé
Signal-anchored (SA) proteins are anchored into the mitochondrial outer membrane (OM) via a single transmembrane segment at their N-terminus while the bulk of the proteins is facing the cytosol. These proteins are encoded by nuclear DNA, translated on cytosolic ribosomes, and are then targeted to the organelle and inserted into its OM by import factors. Recently, research on the insertion mechanisms of these proteins into the mitochondrial OM have gained a lot of attention. In contrast, the early cytosolic steps of their biogenesis are unresolved. Using various proteins from this category and a broad set of in vivo,
Identifiants
pubmed: 35876647
doi: 10.7554/eLife.77706
pii: 77706
pmc: PMC9355564
doi:
pii:
Substances chimiques
HSP70 Heat-Shock Proteins
0
Mitochondrial Membrane Transport Proteins
0
Mitochondrial Precursor Protein Import Complex Proteins
0
Mitochondrial Proteins
0
Molecular Chaperones
0
Peptides
0
Saccharomyces cerevisiae Proteins
0
TOM70 protein, S cerevisiae
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2022, Drwesh et al.
Déclaration de conflit d'intérêts
LD, BH, MG, LK, LH, MF, BM, HK, JB, DR No competing interests declared
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