The altered expression of homing factors in CD34
Antigens, CD34
Cell Adhesion Molecules
Chemokine CXCL12
Granulocyte Colony-Stimulating Factor
/ pharmacology
Hematopoietic Stem Cells
Hemoglobins
Humans
Integrin alpha4beta1
Intercellular Adhesion Molecule-1
Leukocytes, Mononuclear
Matrix Metalloproteinase 9
Precursor Cell Lymphoblastic Leukemia-Lymphoma
/ therapy
Receptors, Chemokine
Vascular Cell Adhesion Molecule-1
G-CSF
acute lymphoblastic leukemia
bone marrow transplantation
hematopoietic stem cell
Journal
Cell biology international
ISSN: 1095-8355
Titre abrégé: Cell Biol Int
Pays: England
ID NLM: 9307129
Informations de publication
Date de publication:
Nov 2022
Nov 2022
Historique:
received:
04
03
2022
accepted:
09
07
2022
pubmed:
27
7
2022
medline:
13
10
2022
entrez:
26
7
2022
Statut:
ppublish
Résumé
Hematopoietic stem cells (HSCs) transplantation is considered a suitable treatment for malignant or nonmalignant hematological diseases. This study aims to investigate the HSCs homing factors in bone marrow (BM) donors of acute lymphoblastic leukemia (ALL) patients following granulocyte colony-stimulating factor (G-CSF) injection, as well as the G-CSF effects on BM transplantation quality in these patients. To mobilize HSCs into peripheral blood, G-CSF was used for ALL patient's BM donors. For HSCs counting, CD34+ cells were evaluated in analogous and autologous donors using flow cytometry. The expression of stem cell homing factors in CD34+ cells and peripheral blood mononuclear cells (PBMCs) were investigated using a real-time polymerase chain reaction. Finally, hematological factors after BM transplantation in ALL patients were assessed. According to our results, after G-CSF injection, the level of CD34+ HSCs was statistically increased. Besides, autologous donors showed a higher level of CD34+ cells compared to analogous donors before and after G-CSF injection. Additionally, a higher number of CD34+ HSCs was achieved in the autologous samples following G-CSF injection. Furthermore, after G-CSF injection, the expression of matrix metalloproteinase (MMP)-2, MMP-9 was increased; while, stromal cell-derived factor 1, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 expression were decreased. Moreover, the expression of C-X-C chemokine receptor type 4, lymphocyte function-associated antigen 1, and very late antigen-4 in CD34+ cells and PBMCs were decreased. BM transplantation on Day 90 also caused an increased level of white blood cells, red blood cells, and platelets as compared to the first day; however, no statistical differences were observed in hemoglobin level. In conclusion, G-CSF by altering the expression of HSCs homing factors in ALL donors improves BM transplantation quality in ALL patients.
Substances chimiques
Antigens, CD34
0
Cell Adhesion Molecules
0
Chemokine CXCL12
0
Hemoglobins
0
Integrin alpha4beta1
0
Receptors, Chemokine
0
Vascular Cell Adhesion Molecule-1
0
Intercellular Adhesion Molecule-1
126547-89-5
Granulocyte Colony-Stimulating Factor
143011-72-7
Matrix Metalloproteinase 9
EC 3.4.24.35
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1876-1885Subventions
Organisme : Hematology Oncology Research Center at Tabriz University of Medical Sciences, Tabriz, Iran
ID : 62486
Informations de copyright
© 2022 International Federation for Cell Biology.
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