The Pro-Inflammatory Deletion Allele of the NF-κB1 Polymorphism Is Characterized by a Depletion of Subunit p50 in Sepsis.
NF-κB
NF-κB1 promoter polymorphism
mitochondrial dysfunction
nuclear factor ‘kappa-light-chain-enhancer’ of activated B-cells
sepsis
subunit p50
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
08 Jul 2022
08 Jul 2022
Historique:
received:
27
05
2022
revised:
01
07
2022
accepted:
07
07
2022
entrez:
27
7
2022
pubmed:
28
7
2022
medline:
29
7
2022
Statut:
epublish
Résumé
The functionally important NF-κB1 promoter polymorphism (-94ins/delATTG) significantly shapes inflammation and impacts the outcome of sepsis. However, exploratory studies elucidating the molecular link of this genotype-dependent pattern are lacking. Accordingly, we analyzed lipopolysaccharide-stimulated peripheral blood mononuclear cells from both healthy volunteers (
Identifiants
pubmed: 35886907
pii: ijms23147559
doi: 10.3390/ijms23147559
pmc: PMC9318670
pii:
doi:
Substances chimiques
Lipopolysaccharides
0
NF-kappa B
0
NF-kappa B p50 Subunit
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
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