Structural network alterations in focal and generalized epilepsy assessed in a worldwide ENIGMA study follow axes of epilepsy risk gene expression.

Adult Connectome Epilepsy Epilepsy, Generalized / genetics Epilepsy, Temporal Lobe / diagnosis Gene Expression Humans Immunoglobulin E Magnetic Resonance Imaging Nerve Net

Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
27 07 2022
Historique:
received: 22 10 2021
accepted: 30 06 2022
entrez: 27 7 2022
pubmed: 28 7 2022
medline: 30 7 2022
Statut: epublish

Résumé

Epilepsy is associated with genetic risk factors and cortico-subcortical network alterations, but associations between neurobiological mechanisms and macroscale connectomics remain unclear. This multisite ENIGMA-Epilepsy study examined whole-brain structural covariance networks in patients with epilepsy and related findings to postmortem epilepsy risk gene expression patterns. Brain network analysis included 578 adults with temporal lobe epilepsy (TLE), 288 adults with idiopathic generalized epilepsy (IGE), and 1328 healthy controls from 18 centres worldwide. Graph theoretical analysis of structural covariance networks revealed increased clustering and path length in orbitofrontal and temporal regions in TLE, suggesting a shift towards network regularization. Conversely, people with IGE showed decreased clustering and path length in fronto-temporo-parietal cortices, indicating a random network configuration. Syndrome-specific topological alterations reflected expression patterns of risk genes for hippocampal sclerosis in TLE and for generalized epilepsy in IGE. These imaging-transcriptomic signatures could potentially guide diagnosis or tailor therapeutic approaches to specific epilepsy syndromes.

Identifiants

DOI: 10.1038/s41467-022-31730-5 PMID: 35896547 PMC: PMC9329287
pubmed: 35896547
doi: 10.1038/s41467-022-31730-5
pii: 10.1038/s41467-022-31730-5
pmc: PMC9329287
doi:

Substances chimiques

Immunoglobulin E 37341-29-0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

4320

Subventions

Organisme : NIBIB NIH HHS
ID : P41 EB015922
Pays : United States
Organisme : Medical Research Council
ID : MR/M00841X/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S00355X/1
Pays : United Kingdom
Organisme : NIBIB NIH HHS
ID : U54 EB020403
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS106957
Pays : United States
Organisme : Medical Research Council
ID : G080212
Pays : United Kingdom
Organisme : NINDS NIH HHS
ID : R21 NS107739
Pays : United States
Organisme : NIMH NIH HHS
ID : T32 MH018399
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS122827
Pays : United States
Organisme : Medical Research Council
ID : MR/K013998/1
Pays : United Kingdom

Informations de copyright

© 2022. The Author(s).

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doi: 10.1038/s42003-020-0794-7

Auteurs

Sara Larivière (S)

Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada. sara.lariviere@mail.mcgill.ca.
ORCID: 0000-0001-5701-1307

Jessica Royer (J)

Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.
ORCID: 0000-0002-4448-8998

Raúl Rodríguez-Cruces (R)

Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.
ORCID: 0000-0002-2917-1212

Casey Paquola (C)

Institute for Neuroscience and Medicine (INM-1), Forschungszentrum Jülich, Jülich, Germany.

Maria Eugenia Caligiuri (ME)

Neuroscience Research Center, University Magna Græcia, Catanzaro, CZ, Italy.

Antonio Gambardella (A)

Neuroscience Research Center, University Magna Græcia, Catanzaro, CZ, Italy.
Institute of Neurology, University Magna Græcia, Catanzaro, CZ, Italy.
ORCID: 0000-0001-7384-3074

Luis Concha (L)

Institute of Neurobiology, Universidad Nacional Autónoma de México, Querétaro, México.
ORCID: 0000-0002-7842-3869

Simon S Keller (SS)

Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
Walton Centre NHS Foundation Trust, Liverpool, UK.

Fernando Cendes (F)

Department of Neurology, University of Campinas-UNICAMP, Campinas, São Paulo, Brazil.

Clarissa L Yasuda (CL)

Department of Neurology, University of Campinas-UNICAMP, Campinas, São Paulo, Brazil.
ORCID: 0000-0001-9084-7173

Leonardo Bonilha (L)

Department of Neurology, Emory University, Atlanta, GA, USA.
ORCID: 0000-0002-6153-8942

Ezequiel Gleichgerrcht (E)

Department of Neurology, Medical University of South Carolina, Charleston, SC, USA.

Niels K Focke (NK)

Department of Neurology, University of Medicine Göttingen, Göttingen, Germany.
ORCID: 0000-0001-5486-6289

Martin Domin (M)

Institute of Diagnostic Radiology and Neuroradiology, Functional Imaging Unit, University Medicine Greifswald, Greifswald, Germany.
ORCID: 0000-0002-8620-966X

Felix von Podewills (F)

Department of Neurology, University Medicine Greifswald, Greifswald, Germany.

Soenke Langner (S)

Institute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany.

Christian Rummel (C)

Support Center for Advanced Neuroimaging (SCAN), University Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern, Bern, Switzerland.

Roland Wiest (R)

Support Center for Advanced Neuroimaging (SCAN), University Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern, Bern, Switzerland.
ORCID: 0000-0001-7030-2045

Pascal Martin (P)

Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.

Raviteja Kotikalapudi (R)

Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.

Terence J O'Brien (TJ)

Department of Neuroscience, Central Clinical School, Alfred Hospital, Monash University, Melbourne, Melbourne, VIC, Australia.
Departments of Medicine and Radiology, The Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC, Australia.

Benjamin Sinclair (B)

Department of Neuroscience, Central Clinical School, Alfred Hospital, Monash University, Melbourne, Melbourne, VIC, Australia.
Departments of Medicine and Radiology, The Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC, Australia.

Lucy Vivash (L)

Department of Neuroscience, Central Clinical School, Alfred Hospital, Monash University, Melbourne, Melbourne, VIC, Australia.
Departments of Medicine and Radiology, The Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC, Australia.

Patricia M Desmond (PM)

Departments of Medicine and Radiology, The Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC, Australia.

Elaine Lui (E)

Departments of Medicine and Radiology, The Royal Melbourne Hospital, The University of Melbourne, Parkville, VIC, Australia.

Anna Elisabetta Vaudano (AE)

Neurology Unit, OCB Hospital, Azienda Ospedaliera-Universitaria, Modena, Italy.
Department of Biomedical, Metabolic and Neural Science, University of Modena and Reggio Emilia, Modena, Italy.

Stefano Meletti (S)

Neurology Unit, OCB Hospital, Azienda Ospedaliera-Universitaria, Modena, Italy.
Department of Biomedical, Metabolic and Neural Science, University of Modena and Reggio Emilia, Modena, Italy.

Manuela Tondelli (M)

Department of Biomedical, Metabolic and Neural Science, University of Modena and Reggio Emilia, Modena, Italy.
Primary Care Department, Azienda Sanitaria Locale di Modena, Modena, Italy.

Saud Alhusaini (S)

Department of Molecular and Cellular Therapeutics, The Royal College of Surgeons in Ireland, Dublin, Ireland.
Department of Neurology, Yale University School of Medicine, New Haven, CT, USA.

Colin P Doherty (CP)

Department of Neurology, St James' Hospital, Dublin, Ireland.
FutureNeuro SFI Research Centre, Dublin, Ireland.

Gianpiero L Cavalleri (GL)

Department of Molecular and Cellular Therapeutics, The Royal College of Surgeons in Ireland, Dublin, Ireland.
FutureNeuro SFI Research Centre, Dublin, Ireland.

Norman Delanty (N)

Department of Molecular and Cellular Therapeutics, The Royal College of Surgeons in Ireland, Dublin, Ireland.
FutureNeuro SFI Research Centre, Dublin, Ireland.

Reetta Kälviäinen (R)

Epilepsy Center, Neuro Center, Kuopio University Hospital, Member of the European Reference Network for Rare and Complex Epilepsies EpiCARE, Kuopio, Finland.
Faculty of Health Sciences, School of Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.

Graeme D Jackson (GD)

Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC, 3010, Australia.

Magdalena Kowalczyk (M)

Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC, 3010, Australia.

Mario Mascalchi (M)

Neuroradiology Research Program, Meyer Children Hospital of Florence, University of Florence, Florence, Italy.

Mira Semmelroch (M)

Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC, 3010, Australia.

Rhys H Thomas (RH)

Transitional and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.

Hamid Soltanian-Zadeh (H)

Contol and Intelligent Processing Center of Excellence (CIPCE), School of Electrical and Computer Engineering, University of Tehran, Tehran, Iran.
Departments of Research Administration and Radiology, Henry Ford Health System, Detroit, MI, USA.
ORCID: 0000-0002-7302-6856

Esmaeil Davoodi-Bojd (E)

Department of Neurology, Henry Ford Health System, Detroit, MI, USA.

Junsong Zhang (J)

Cognitive Science Department, Xiamen University, Xiamen, China.

Gavin P Winston (GP)

Division of Neurology, Department of Medicine, Queen's University, Kingston, ON, Canada.
Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK.
Chalfont Centre for Epilepsy, Bucks, UK.

Aoife Griffin (A)

Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry & Biomedical Science, Queens University Belfast, Belfast, UK.
ORCID: 0000-0002-9828-5117

Aditi Singh (A)

Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry & Biomedical Science, Queens University Belfast, Belfast, UK.

Vijay K Tiwari (VK)

Wellcome-Wolfson Institute for Experimental Medicine, School of Medicine, Dentistry & Biomedical Science, Queens University Belfast, Belfast, UK.
ORCID: 0000-0003-0292-6635

Barbara A K Kreilkamp (BAK)

Department of Neurology, University of Medicine Göttingen, Göttingen, Germany.

Matteo Lenge (M)

Child Neurology Unit and Laboratories, Neuroscience Department, Children's Hospital A. Meyer-University of Florence, Florence, Italy.
Functional and Epilepsy Neurosurgery Unit, Neurosurgery Department, Children's Hospital A. Meyer-University of Florence, Florence, Italy.
ORCID: 0000-0003-2848-621X

Renzo Guerrini (R)

Child Neurology Unit and Laboratories, Neuroscience Department, Children's Hospital A. Meyer-University of Florence, Florence, Italy.

Khalid Hamandi (K)

The Welsh Epilepsy Unit, Department of Neurology, University Hospital of Whales, Cardiff, UK.
Cardiff University Brain Research Imaging Centre (CUBRIC), College of Biomedical Sciences, Cardiff University, Cardiff, UK.

Sonya Foley (S)

Cardiff University Brain Research Imaging Centre (CUBRIC), College of Biomedical Sciences, Cardiff University, Cardiff, UK.
ORCID: 0000-0002-8390-2709

Theodor Rüber (T)

Department of Epileptology, University of Bonn Medical Center, Bonn, Germany.
Epilepsy Center Frankfurt Rhine-Main, Department of Neurology, Goethe-University Frankfurt, Frankfurt am Main, Germany.
Center for Personalized Translational Epilepsy Research (CePTER), Goethe-University Frankfurt, Frankfurt am Main, Germany.
ORCID: 0000-0002-6180-7671

Bernd Weber (B)

Institute of Experimental Epileptology and Cognition Research, University Hospital Bonn, Bonn, Germany.

Chantal Depondt (C)

Department of Neurology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.

Julie Absil (J)

Department of Radiology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.

Sarah J A Carr (SJA)

Division of Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

Eugenio Abela (E)

Division of Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

Mark P Richardson (MP)

Division of Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

Orrin Devinsky (O)

Department of Neurology, NYU Grossman School of Medicine, New York, NY, US.
ORCID: 0000-0003-0044-4632

Mariasavina Severino (M)

IRCCS Istituto Giannina Gaslini, Genova, Italy.

Pasquale Striano (P)

IRCCS Istituto Giannina Gaslini, Genova, Italy.
Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy.
ORCID: 0000-0002-6065-1476

Domenico Tortora (D)

Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genova, Italy.

Erik Kaestner (E)

Department of Psychiatry, Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, CA, US.

Sean N Hatton (SN)

Department of Neurosciences, Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, CA, US.
ORCID: 0000-0002-9149-8726

Sjoerd B Vos (SB)

Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK.
Chalfont Centre for Epilepsy, Bucks, UK.
Centre for Medical Image Computing, University College London, London, UK.
ORCID: 0000-0002-8502-4487

Lorenzo Caciagli (L)

Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK.
Chalfont Centre for Epilepsy, Bucks, UK.

John S Duncan (JS)

Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK.
Chalfont Centre for Epilepsy, Bucks, UK.
ORCID: 0000-0002-1373-0681

Christopher D Whelan (CD)

Department of Molecular and Cellular Therapeutics, The Royal College of Surgeons in Ireland, Dublin, Ireland.

Paul M Thompson (PM)

Imaging Genetics Center, Mark & Mary Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, Los Angeles, CA, US.

Sanjay M Sisodiya (SM)

Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK.
Chalfont Centre for Epilepsy, Bucks, UK.

Andrea Bernasconi (A)

Neuroimaging of Epilepsy Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.

Angelo Labate (A)

Neurology, BIOMORF Dipartment, University of Messina, Messina, Italy.
ORCID: 0000-0002-8827-7324

Carrie R McDonald (CR)

Department of Psychiatry, Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, CA, US.

Neda Bernasconi (N)

Neuroimaging of Epilepsy Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.

Boris C Bernhardt (BC)

Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada. boris.bernhardt@mcgill.ca.
ORCID: 0000-0001-9256-6041

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Structural network alterations in focal and...
questionsmedicales.fr › Techniques d'investigation › Neuroimagerie › Neuroimagerie fonctionnelle › Cartographie cérébrale › Connectome › Structural network alterations in focal and...
questionsmedicales.fr › Maladies du système nerveux › Maladies du système nerveux central › Encéphalopathies › Épilepsie › Structural network alterations in focal and...
questionsmedicales.fr › Maladies du système nerveux › Maladies du système nerveux central › Encéphalopathies › Épilepsie › Épilepsie généralisée › Structural network alterations in focal and...
questionsmedicales.fr › Maladies du système nerveux › Maladies du système nerveux central › Encéphalopathies › Épilepsie › Syndromes épileptiques › Épilepsie temporale › Structural network alterations in focal and...
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › Structural network alterations in focal and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Structural network alterations in focal and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Isotypes des immunoglobulines › Immunoglobuline E › Structural network alterations in focal and...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Structural network alterations in focal and...
questionsmedicales.fr › Système nerveux › Réseau nerveux › Structural network alterations in focal and...