Neural crest mechanosensors: Seeing old proteins in a new light.
GPCR
ion channels
mechanics
mechanotransduction
neural crest
Journal
Developmental cell
ISSN: 1878-1551
Titre abrégé: Dev Cell
Pays: United States
ID NLM: 101120028
Informations de publication
Date de publication:
08 08 2022
08 08 2022
Historique:
received:
31
03
2022
revised:
26
05
2022
accepted:
05
07
2022
pubmed:
29
7
2022
medline:
12
8
2022
entrez:
28
7
2022
Statut:
ppublish
Résumé
Mechanical forces exerted on neural crest cells control their collective migration and differentiation. This perspective discusses our current understanding of neural crest mechanotransduction during cell migration and differentiation. Additionally, we describe proteins that have mechanosensitive functions in other systems, such as mechanosensitive G-protein-coupled receptors, mechanosensitive ion channels, cell-cell adhesion, and cell-matrix-interacting proteins, and highlight that these same proteins have in the past been studied in neural crest development from a purely signaling point of view. We propose that future studies elucidate the mechanosensitive functions these receptors may play in neural crest development and integrate this with their known molecular role.
Identifiants
pubmed: 35901790
pii: S1534-5807(22)00494-4
doi: 10.1016/j.devcel.2022.07.005
pii:
doi:
Substances chimiques
Cytoskeletal Proteins
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1792-1801Subventions
Organisme : Medical Research Council
ID : MR/S007792/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : M008517
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 102489/Z/13/Z
Pays : United Kingdom
Informations de copyright
Copyright © 2022 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.