Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19.

3-Hydroxybutyric Acid / biosynthesis Amino Acids / biosynthesis Animals COVID-19 / complications Diet, Ketogenic Energy Metabolism Esters / metabolism Glutathione / biosynthesis Glycolysis Interferon-gamma / biosynthesis Ketone Bodies / metabolism Ketones / metabolism Mice Orthomyxoviridae / pathogenicity Oxidation-Reduction Oxidative Phosphorylation Respiratory Distress Syndrome / complications SARS-CoV-2 / pathogenicity T-Lymphocytes / immunology

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
09 2022
Historique:
received: 28 07 2021
accepted: 20 07 2022
pubmed: 29 7 2022
medline: 24 9 2022
entrez: 28 7 2022
Statut: ppublish

Résumé

Anorexia and fasting are host adaptations to acute infection, and induce a metabolic switch towards ketogenesis and the production of ketone bodies, including β-hydroxybutyrate (BHB)

Identifiants

DOI: 10.1038/s41586-022-05128-8 PMID: 35901960 PMC: PMC9428867
pubmed: 35901960
doi: 10.1038/s41586-022-05128-8
pii: 10.1038/s41586-022-05128-8
pmc: PMC9428867
doi:

Substances chimiques

Amino Acids 0
Esters 0
Ketone Bodies 0
Ketones 0
Interferon-gamma 82115-62-6
Glutathione GAN16C9B8O
3-Hydroxybutyric Acid TZP1275679

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

801-807

Investigateurs

Zeinab Abdullah (Z)
Eicke Latz (E)
Susanne Schmidt (S)
Gunther Hartmann (G)
Hendrik Streeck (H)
Beate M Kümmerer (BM)

Commentaires et corrections

Type : CommentIn

Informations de copyright

© 2022. The Author(s), under exclusive licence to Springer Nature Limited.

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Auteurs

Fotios Karagiannis (F)

Immunopathology Unit, Institute of Clinical Chemistry and Clinical Pharmacology, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany.
ORCID: 0000-0002-1030-0635

Konrad Peukert (K)

Department of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, Bonn, Germany.

Laura Surace (L)

Immunopathology Unit, Institute of Clinical Chemistry and Clinical Pharmacology, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany.
Department of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, Bonn, Germany.
ORCID: 0000-0001-8152-0611

Marcel Michla (M)

Immunopathology Unit, Institute of Clinical Chemistry and Clinical Pharmacology, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany.

Fabian Nikolka (F)

Department of Bioinformatics and Biochemistry, Braunschweig Integrated Center of Systems Biology, Technische Universität Braunschweig, Brunswick, Germany.

Mario Fox (M)

Department of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, Bonn, Germany.

Patricia Weiss (P)

Immunopathology Unit, Institute of Clinical Chemistry and Clinical Pharmacology, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany.

Caroline Feuerborn (C)

Department of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, Bonn, Germany.

Paul Maier (P)

Immunopathology Unit, Institute of Clinical Chemistry and Clinical Pharmacology, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany.
ORCID: 0000-0001-6606-3926

Susanne Schulz (S)

Department of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, Bonn, Germany.

Burcu Al (B)

Immunology and Metabolism Unit, Life & Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany.

Benjamin Seeliger (B)

Department of Respiratory Medicine and German Centre of Lung Research (DZL), Hannover Medical School, Hannover, Germany.
ORCID: 0000-0001-7373-752X

Tobias Welte (T)

Department of Respiratory Medicine and German Centre of Lung Research (DZL), Hannover Medical School, Hannover, Germany.
ORCID: 0000-0002-9947-7356

Sascha David (S)

Institute of Intensive Care Medicine, University Hospital Zürich, Zürich, Switzerland.

Inge Grondman (I)

Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.

Aline H de Nooijer (AH)

Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.
ORCID: 0000-0002-7718-0471

Peter Pickkers (P)

Department of Intensive Care Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.

Jan Lukas Kleiner (JL)

Department of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, Bonn, Germany.

Marc Moritz Berger (MM)

Department of Anesthesiology and Intensive Care Medicine, University Hospital Essen, University Duisburg-Essen, Essen, Germany.
ORCID: 0000-0001-6771-3193

Thorsten Brenner (T)

Department of Anesthesiology and Intensive Care Medicine, University Hospital Essen, University Duisburg-Essen, Essen, Germany.

Christian Putensen (C)

Department of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, Bonn, Germany.

Hiroki Kato (H)

Institute of Cardiovascular Immunology, University Hospital Bonn, University of Bonn, Bonn, Germany.

Natalio Garbi (N)

Institute of Experimental Immunology, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany.

Mihai G Netea (MG)

Immunology and Metabolism Unit, Life & Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany.
Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.
ORCID: 0000-0003-2421-6052

Karsten Hiller (K)

Department of Bioinformatics and Biochemistry, Braunschweig Integrated Center of Systems Biology, Technische Universität Braunschweig, Brunswick, Germany.
ORCID: 0000-0001-9322-5820

Katarzyna Placek (K)

Immunology and Metabolism Unit, Life & Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany.

Christian Bode (C)

Department of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, Bonn, Germany. christian.bode@ukbonn.de.
ORCID: 0000-0002-0830-870X

Christoph Wilhelm (C)

Immunopathology Unit, Institute of Clinical Chemistry and Clinical Pharmacology, Medical Faculty, University Hospital Bonn, University of Bonn, Bonn, Germany. christoph.wilhelm@uni-bonn.de.
ORCID: 0000-0002-9839-0291

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Classifications MeSH

questionsmedicales.fr › Lipides › Acides gras › Acides gras volatils › Butyrates › Hydroxy-butyrates › Acide 3-hydroxy-butyrique › Impaired ketogenesis ties metabolism to T cell...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Impaired ketogenesis ties metabolism to T cell...
questionsmedicales.fr › Eucaryotes › Animaux › Impaired ketogenesis ties metabolism to T cell...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Impaired ketogenesis ties metabolism to T cell...
questionsmedicales.fr › Phénomènes physiologiques › Alimentation et nutrition › Phénomènes physiologiques nutritionnels › Régime alimentaire › Régime pauvre en glucides › Régime cétogène › Impaired ketogenesis ties metabolism to T cell...
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Impaired ketogenesis ties metabolism to T cell...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Esters › Impaired ketogenesis ties metabolism to T cell...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Oligopeptides › Glutathion › Impaired ketogenesis ties metabolism to T cell...
questionsmedicales.fr › Métabolisme › Voies et réseaux métaboliques › Glycolyse › Impaired ketogenesis ties metabolism to T cell...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Lymphokines › Facteurs d'activation des macrophages › Interféron gamma › Impaired ketogenesis ties metabolism to T cell...
questionsmedicales.fr › Composés chimiques organiques › Cétones › Corps cétoniques › Impaired ketogenesis ties metabolism to T cell...
questionsmedicales.fr › Composés chimiques organiques › Cétones › Impaired ketogenesis ties metabolism to T cell...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Impaired ketogenesis ties metabolism to T cell...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN de polarité négative › Orthomyxoviridae › Impaired ketogenesis ties metabolism to T cell...
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Oxydoréduction › Impaired ketogenesis ties metabolism to T cell...
questionsmedicales.fr › Métabolisme › Phosphorylation › Phosphorylation oxydative › Impaired ketogenesis ties metabolism to T cell...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Troubles respiratoires › Syndrome de détresse respiratoire de l'adulte › Impaired ketogenesis ties metabolism to T cell...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › Impaired ketogenesis ties metabolism to T cell...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Impaired ketogenesis ties metabolism to T cell...