Lineage- and Stage-Specific Oncogenicity of IRF4.

Cell Differentiation Hematopoiesis Interferon Regulatory Factors / genetics Lymphocyte Activation Oncogenes

Journal

Experimental hematology
ISSN: 1873-2399
Titre abrégé: Exp Hematol
Pays: Netherlands
ID NLM: 0402313

Informations de publication

Date de publication:
10 2022
Historique:
received: 13 06 2022
revised: 22 07 2022
accepted: 25 07 2022
pubmed: 1 8 2022
medline: 5 10 2022
entrez: 31 7 2022
Statut: ppublish

Résumé

Dysregulation of transcription factor genes represents a unique molecular etiology of hematological malignancies. A number of transcription factors that play a role in hematopoietic cell development, lymphocyte activation, or their maintenance have been identified as oncogenes or tumor suppressors. Many of them exert oncogenic abilities in a context-dependent manner by governing the key transcriptional program unique to each cell type. IRF4, a member of the interferon regulatory factor (IRF) family, acts as an essential regulator of the immune system and is a prime example of a stage-specific oncogene. The expression and oncogenicity of IRF4 are restricted to mature lymphoid neoplasms, while IRF4 potentially serves as a tumor suppressor in other cellular contexts. This is in marked contrast to its immediate downstream target, MYC, which can cause cancers in a variety of tissues. In this review article, we provide an overview of the roles of IRF4 in the development of the normal immune system and lymphoid neoplasms and discuss the potential mechanisms of lineage- and stage-specific oncogenicity of IRF4.

Identifiants

DOI: 10.1016/j.exphem.2022.07.300 PMID: 35908629
pubmed: 35908629
pii: S0301-472X(22)00578-1
doi: 10.1016/j.exphem.2022.07.300
pii:
doi:

Substances chimiques

Interferon Regulatory Factors 0

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

9-17

Informations de copyright

Copyright © 2022 ISEH -- Society for Hematology and Stem Cells. Published by Elsevier Inc. All rights reserved.

Auteurs

Stella Amanda (S)

Cancer Science Institute of Singapore, National University of Singapore, Singapore.

Tze King Tan (TK)

Cancer Science Institute of Singapore, National University of Singapore, Singapore.

Shinsuke Iida (S)

Department of Hematology and Oncology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi, Japan.

Takaomi Sanda (T)

Cancer Science Institute of Singapore, National University of Singapore, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. Electronic address: takaomi_sanda@nus.edu.sg.

Articles similaires

Decorin-armed oncolytic adenovirus promotes natural killers (NKs) activation and infiltration to enhance NK therapy in CRC model.

Xue Li, Yuning Zhang, Zhuang Mao et al.
1.00
Killer Cells, Natural Animals Colorectal Neoplasms Decorin Adenoviridae

A key role for P2RX5 in brown adipocyte differentiation and energy homeostasis.

Maria Razzoli, Seth McGonigle, Bhavani Shankar Sahu et al.
1.00
Animals Adipocytes, Brown Mice Cell Differentiation Male

Identification of CD141

Gabee Park, Dae Yeon Hwang, Do Young Kim et al.
1.00
Humans Mesenchymal Stem Cells Animals Mice Mesenchymal Stem Cell Transplantation

DPP an extracellular matrix molecule induces Wnt5a mediated signaling to promote the differentiation of adult stem cells into odontogenic lineage.

Yinghua Chen, Adrienn Petho, Amudha Ganapathy et al.
1.00
Wnt-5a Protein Animals Cell Differentiation Odontogenesis Humans

Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Lineage- and Stage-Specific Oncogenicity of IRF4.
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiogiques du sang › Hématopoïèse › Lineage- and Stage-Specific Oncogenicity of IRF4.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de régulation d'interféron › Lineage- and Stage-Specific Oncogenicity of IRF4.
questionsmedicales.fr › Phénomènes du système immunitaire › Activation des lymphocytes › Lineage- and Stage-Specific Oncogenicity of IRF4.
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Gènes tumoraux › Oncogènes › Lineage- and Stage-Specific Oncogenicity of IRF4.