Regulation of mitochondrial proteostasis by the proton gradient.
AFG3L2
TMBIM5
mitochondrial calcium
proton gradient
respiratory chain
Journal
The EMBO journal
ISSN: 1460-2075
Titre abrégé: EMBO J
Pays: England
ID NLM: 8208664
Informations de publication
Date de publication:
16 08 2022
16 08 2022
Historique:
revised:
29
06
2022
received:
17
12
2021
accepted:
01
07
2022
pubmed:
2
8
2022
medline:
18
8
2022
entrez:
1
8
2022
Statut:
ppublish
Résumé
Mitochondria adapt to different energetic demands reshaping their proteome. Mitochondrial proteases are emerging as key regulators of these adaptive processes. Here, we use a multiproteomic approach to demonstrate the regulation of the m-AAA protease AFG3L2 by the mitochondrial proton gradient, coupling mitochondrial protein turnover to the energetic status of mitochondria. We identify TMBIM5 (previously also known as GHITM or MICS1) as a Ca
Identifiants
pubmed: 35912435
doi: 10.15252/embj.2021110476
pmc: PMC9379554
doi:
Substances chimiques
Mitochondrial Proteins
0
Proteome
0
Protons
0
ATP-Dependent Proteases
EC 3.4.21.-
ATPases Associated with Diverse Cellular Activities
EC 3.6.4.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e110476Informations de copyright
© 2022 The Authors. Published under the terms of the CC BY 4.0 license.
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