The effect of cladribine tablets in people with more active multiple sclerosis: a plain language summary.


Journal

Neurodegenerative disease management
ISSN: 1758-2032
Titre abrégé: Neurodegener Dis Manag
Pays: England
ID NLM: 101517977

Informations de publication

Date de publication:
12 2022
Historique:
pubmed: 4 8 2022
medline: 27 10 2022
entrez: 3 8 2022
Statut: ppublish

Résumé

This article summarizes the findings from a previously published article in Researchers found that in people with more active MS, treatment with cladribine tablets led to a lower risk of relapse and there were more people who had no relapses. People also had a lower chance of their MS worsening and had fewer new lesions in the brain. These benefits were seen regardless of whether the participants had prior treatment. Researchers concluded that in these people with more active MS, treatment with cladribine tablets led to better outcomes over 2 years compared with treatment with placebo tablets, regardless of whether the participants had taken any prior MS treatments.

Identifiants

pubmed: 35920065
doi: 10.2217/nmt-2022-0009
doi:

Substances chimiques

Cladribine 47M74X9YT5
Immunosuppressive Agents 0
Tablets 0

Banques de données

ClinicalTrials.gov
['NCT00213135']

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

285-293

Auteurs

Patrick Vermersch (P)

Univ. Lille, INSERM U1172, Lille Neurosciences & Cognition, CHU Lille, FHU Precise, Lille, France.

Andrew Galazka (A)

Merck Healthcare KGaA, Darmstadt, Germany.

Fernando Dangond (F)

EMD Serono Research & Development Institute Inc., Billerica, MA, USA, an affiliate of Merck KGaA.

Doris Damian (D)

EMD Serono Research & Development Institute Inc., Billerica, MA, USA, an affiliate of Merck KGaA.

Schiffon L Wong (SL)

EMD Serono Research & Development Institute Inc., Billerica, MA, USA, an affiliate of Merck KGaA.

Dominic Jack (D)

Merck Serono Ltd., Feltham, UK, an affiliate of Merck KGaA.

Gerard Harty (G)

Merck Healthcare KGaA, Darmstadt, Germany.

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Classifications MeSH