Wound healing in aged skin exhibits systems-level alterations in cellular composition and cell-cell communication.
CP: Cell biology
CP: Developmental biology
aging
cell-cell communication
cellular heterogeneity
dendritic cell
macrophage
neutrophil
signaling
single-cell RNA-seq
skin
wound healing
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
02 08 2022
02 08 2022
Historique:
received:
09
12
2021
revised:
13
05
2022
accepted:
12
07
2022
entrez:
4
8
2022
pubmed:
5
8
2022
medline:
9
8
2022
Statut:
ppublish
Résumé
Delayed and often impaired wound healing in the elderly presents major medical and socioeconomic challenges. A comprehensive understanding of the cellular/molecular changes that shape complex cell-cell communications in aged skin wounds is lacking. Here, we use single-cell RNA sequencing to define the epithelial, fibroblast, immune cell types, and encompassing heterogeneities in young and aged skin during homeostasis and identify major changes in cell compositions, kinetics, and molecular profiles during wound healing. Our comparative study uncovers a more pronounced inflammatory phenotype in aged skin wounds, featuring neutrophil persistence and higher abundance of an inflammatory/glycolytic Arg1
Identifiants
pubmed: 35926463
pii: S2211-1247(22)00964-0
doi: 10.1016/j.celrep.2022.111155
pmc: PMC9901190
mid: NIHMS1866797
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
111155Subventions
Organisme : NIAMS NIH HHS
ID : R01 AR068074
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM123731
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM145307
Pays : United States
Organisme : NIAMS NIH HHS
ID : U01 AR073159
Pays : United States
Organisme : NIAMS NIH HHS
ID : P30 AR075047
Pays : United States
Informations de copyright
Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.
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