Molecular Epidemiology of Mycobacterium abscessus Isolates Recovered from German Cystic Fibrosis Patients.

German CF registry Mycobacterium abscessus cystic fibrosis dominant circulating clones hospital transmission nontuberculous mycobacteria whole-genome sequencing

Journal

Microbiology spectrum
ISSN: 2165-0497
Titre abrégé: Microbiol Spectr
Pays: United States
ID NLM: 101634614

Informations de publication

Date de publication:
31 08 2022
Historique:
pubmed: 9 8 2022
medline: 9 9 2022
entrez: 8 8 2022
Statut: ppublish

Résumé

Infections due to Mycobacterium abscessus are a major cause of mortality and morbidity in cystic fibrosis (CF) patients. Furthermore, M. abscessus has been suspected to be involved in person-to-person transmissions. In 2016, dominant global clonal complexes (DCCs) that occur worldwide among CF patients have been described. To elucidate the epidemiological situation of M. abscessus among CF patients in Germany and to put these data into a global context, we performed whole-genome sequencing of a set of 154 M. abscessus isolates from 123 German patients treated in 14 CF centers. We used MTBseq pipeline to identify clusters of closely related isolates and correlate those with global findings. Genotypic drug susceptibility for macrolides and aminoglycosides was assessed by characterization of the

Identifiants

pubmed: 35938728
doi: 10.1128/spectrum.01714-22
pmc: PMC9431180
doi:

Substances chimiques

Anti-Bacterial Agents 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0171422

Références

Clin Chest Med. 2016 Mar;37(1):83-96
pubmed: 26857770
PeerJ. 2018 Nov 13;6:e5895
pubmed: 30479891
Virulence. 2021 Dec;12(1):2415-2429
pubmed: 34546836
Clin Transplant. 2013 Jul-Aug;27(4):523-9
pubmed: 23710571
Bioinformatics. 2014 May 1;30(9):1312-3
pubmed: 24451623
J Clin Microbiol. 2020 Jun 24;58(7):
pubmed: 32295892
Eur Respir J. 2020 Jul 7;56(1):
pubmed: 32636299
PLoS One. 2015 May 22;10(5):e0128036
pubmed: 26000737
Biomed Res Int. 2015;2015:197950
pubmed: 26106603
J Clin Microbiol. 2020 Nov 18;58(12):
pubmed: 32938741
Antimicrob Agents Chemother. 2019 Jul 25;63(8):
pubmed: 31160290
Eur Respir J. 2019 Jul 11;54(1):
pubmed: 30880280
Ann Am Thorac Soc. 2018 Jul;15(7):817-826
pubmed: 29897781
Lancet. 2013 May 4;381(9877):1551-60
pubmed: 23541540
Eur Respir J. 2017 Jul 13;50(1):
pubmed: 28705942
Thorax. 2016 Jan;71(1):88-90
pubmed: 26678435
Am J Respir Crit Care Med. 2007 Feb 15;175(4):367-416
pubmed: 17277290
Semin Respir Crit Care Med. 2019 Dec;40(6):737-750
pubmed: 31659731
MMWR Morb Mortal Wkly Rep. 2014 Mar 7;63(9):201-2
pubmed: 24598597
Nat Microbiol. 2021 Oct;6(10):1279-1288
pubmed: 34545208
Lancet Microbe. 2021 Oct;2(10):e498-e507
pubmed: 34632432
Int J Syst Evol Microbiol. 2016 Nov;66(11):4471-4479
pubmed: 27499141
Science. 2021 Apr 30;372(6541):
pubmed: 33926925
Science. 2016 Nov 11;354(6313):751-757
pubmed: 27846606
Front Microbiol. 2018 Dec 05;9:2988
pubmed: 30568642
Transpl Infect Dis. 2020 Jun;22(3):e13274
pubmed: 32129923
J Cyst Fibros. 2010 Mar;9(2):117-23
pubmed: 20071249
BMC Res Notes. 2013 Dec 28;6:561
pubmed: 24373461
Curr Opin Pulm Med. 2019 Nov;25(6):646-653
pubmed: 31436542
Nat Commun. 2021 Aug 26;12(1):5145
pubmed: 34446725
J Antimicrob Chemother. 2012 Nov;67(11):2606-11
pubmed: 22833642
J Antimicrob Chemother. 2014 Jun;69(6):1559-63
pubmed: 24500188
J Infect Dis. 1998 Jun;177(6):1573-81
pubmed: 9607835
J Cyst Fibros. 2015 Jan;14(1):46-52
pubmed: 25178871
Transpl Infect Dis. 2019 Apr;21(2):e13046
pubmed: 30597699
Int J Mol Sci. 2019 Nov 22;20(23):
pubmed: 31766758

Auteurs

Nils Wetzstein (N)

Department of Internal Medicine, Infectious Diseases, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany.

Margo Diricks (M)

German Center for Infection Research (DZIF), partner site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany.
Molecular and Experimental Mycobacteriology, Research Center Borstel, Borstel, Germany.

Thomas A Kohl (TA)

German Center for Infection Research (DZIF), partner site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany.
Molecular and Experimental Mycobacteriology, Research Center Borstel, Borstel, Germany.

Thomas A Wichelhaus (TA)

Institute of Medical Microbiology and Infection Control, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany.

Sönke Andres (S)

German Center for Infection Research (DZIF), partner site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany.
National and WHO Supranational Reference Laboratory for Mycobacteria, Research Center Borstel, Leibniz Lung Center, Borstel, Germany.

Laura Paulowski (L)

German Center for Infection Research (DZIF), partner site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany.
National and WHO Supranational Reference Laboratory for Mycobacteria, Research Center Borstel, Leibniz Lung Center, Borstel, Germany.

Carsten Schwarz (C)

Division of Cystic Fibrosis, Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Division of Cystic Fibrosis, CF Center Westbrandenburg, Campus Potsdam, Klinikum Potsdam, Potsdam, Germany.

Astrid Lewin (A)

Unit Mycotic and Parasitic Agents and Mycobacteria, Robert Koch Institute, Berlin, Germany.

Jan Kehrmann (J)

Institute of Medical Microbiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany.

Barbara C Kahl (BC)

Institute of Medical Microbiology, University Hospital Münster, Münster, Germany.

Karl Dichtl (K)

Max von Pettenkofer Institut, Institute of Medical Microbiology and Hygiene, Medizinische Fakultät, Ludwig-Maximilians-Universität, Munich, Germany.

Christian Hügel (C)

Department of Respiratory Medicine and Allergology, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany.
Christiane Herzog CF Center, Medical Clinic, Department of Respiratory Medicine and Allergology, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany.

Olaf Eickmeier (O)

Division for Allergy, Pneumology and Cystic Fibrosis, Department for Children and Adolescence, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany.

Christina Smaczny (C)

Department of Respiratory Medicine and Allergology, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany.
Christiane Herzog CF Center, Medical Clinic, Department of Respiratory Medicine and Allergology, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany.

Annika Schmidt (A)

Interfaculty Institute of Microbiology and Infection Medicine Tübingen, Insitute for Medical Microbiology and Hygiene, University Hospital Tübingen, Tübingen, Germany.

Stefan Zimmermann (S)

Department of Infectious Diseases, Medical Microbiology and Hygiene, Heidelberg University Hospital, Heidelberg, Germany.

Lutz Nährlich (L)

Department of Pediatrics, Justus-Liebig-University Giessen, Giessen, Germany.

Sylvia Hafkemeyer (S)

Mukoviszidose Institut, gemeinnützige Gesellschaft für Forschung und Therapieentwicklung mbH, Bonn, Germany.

Stefan Niemann (S)

German Center for Infection Research (DZIF), partner site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany.
Molecular and Experimental Mycobacteriology, Research Center Borstel, Borstel, Germany.

Florian P Maurer (FP)

German Center for Infection Research (DZIF), partner site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany.
National and WHO Supranational Reference Laboratory for Mycobacteria, Research Center Borstel, Leibniz Lung Center, Borstel, Germany.
Institute of Medical Microbiology, Virology and Hospital Hygiene, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Michael Hogardt (M)

Institute of Medical Microbiology and Infection Control, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany.
German National Consiliary Laboratory on Cystic Fibrosis Bacteriology, Frankfurt am Main, Germany.

Articles similaires

Genome, Chloroplast Phylogeny Genetic Markers Base Composition High-Throughput Nucleotide Sequencing

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female
Humans United States Aged Cross-Sectional Studies Medicare Part C

Classifications MeSH