Hormone- and antibody-mediated activation of the thyrotropin receptor.

Graves Disease / immunology Humans Immunoglobulins, Thyroid-Stimulating / immunology Membrane Microdomains Receptors, LH Receptors, Thyrotropin / agonists Thyrotropin / metabolism

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
09 2022
Historique:
received: 19 01 2022
accepted: 02 08 2022
pubmed: 9 8 2022
medline: 24 9 2022
entrez: 8 8 2022
Statut: ppublish

Résumé

Thyroid-stimulating hormone (TSH), through activation of its G-protein-coupled thyrotropin receptor (TSHR), controls the synthesis of thyroid hormone-an essential metabolic hormone

Identifiants

DOI: 10.1038/s41586-022-05173-3 PMID: 35940204
pubmed: 35940204
doi: 10.1038/s41586-022-05173-3
pii: 10.1038/s41586-022-05173-3
doi:

Substances chimiques

Immunoglobulins, Thyroid-Stimulating 0
LHCGR protein, human 0
Receptors, LH 0
Receptors, Thyrotropin 0
Thyrotropin 9002-71-5

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

854-859

Informations de copyright

© 2022. The Author(s), under exclusive licence to Springer Nature Limited.

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Auteurs

Jia Duan (J)

The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
University of Chinese Academy of Sciences, Beijing, China.

Peiyu Xu (P)

The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
ORCID: 0000-0003-3590-4037

Xiaodong Luan (X)

Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
Medical Research Center, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
School of Medicine, Tsinghua University, Beijing, China.
Tsinghua-Peking Center for life science, Tsinghua University, Beijing, China.
ORCID: 0000-0002-1279-5432

Yujie Ji (Y)

The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
University of Chinese Academy of Sciences, Beijing, China.

Xinheng He (X)

The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
University of Chinese Academy of Sciences, Beijing, China.
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
ORCID: 0000-0001-7813-5480

Ning Song (N)

University of Chinese Academy of Sciences, Beijing, China.
Center of Immunological Diseases, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.

Qingning Yuan (Q)

The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.

Ye Jin (Y)

Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
Medical Research Center, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.

Xi Cheng (X)

State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
ORCID: 0000-0003-3735-645X

Hualiang Jiang (H)

University of Chinese Academy of Sciences, Beijing, China.
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
ORCID: 0000-0003-0656-6315

Jie Zheng (J)

Center of Immunological Diseases, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.

Shuyang Zhang (S)

Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China. shuyangzhang103@nrdrs.org.
Medical Research Center, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China. shuyangzhang103@nrdrs.org.
School of Medicine, Tsinghua University, Beijing, China. shuyangzhang103@nrdrs.org.
Tsinghua-Peking Center for life science, Tsinghua University, Beijing, China. shuyangzhang103@nrdrs.org.
ORCID: 0000-0002-1532-0029

Yi Jiang (Y)

School of Life Science and Technology, ShanghaiTech University, Shanghai, China. yjiang@lglab.ac.cn.
Lingang Laboratory, Shanghai, China. yjiang@lglab.ac.cn.
ORCID: 0000-0002-0723-1413

H Eric Xu (HE)

The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China. eric.xu@simm.ac.cn.
University of Chinese Academy of Sciences, Beijing, China. eric.xu@simm.ac.cn.
School of Life Science and Technology, ShanghaiTech University, Shanghai, China. eric.xu@simm.ac.cn.
ORCID: 0000-0002-6829-8144

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Classifications MeSH

questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Maladie de Basedow › Hormone- and antibody-mediated activation of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Hormone- and antibody-mediated activation of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Autoanticorps › Immunoglobulines thyréostimulantes › Hormone- and antibody-mediated activation of...
questionsmedicales.fr › Cellules › Structures cellulaires › Membrane cellulaire › Structures de la membrane cellulaire › Microdomaines membranaires › Hormone- and antibody-mediated activation of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur hormone hypophysaire › Récepteur gonadotrophine › Récepteur LH › Hormone- and antibody-mediated activation of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur hormone hypophysaire › Récepteur TSH › Hormone- and antibody-mediated activation of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormones hypophysaires › Hormones antéhypophysaires › Thyréostimuline › Hormone- and antibody-mediated activation of...