The drp-1-mediated mitochondrial fission inhibitor mdivi-1 impacts the function of ion channels and pathways underpinning vascular smooth muscle tone.
Ca(V)1.2 channels
K(Ca)1.1 channels
Mdivi-1
Mitochondrial fission
Molecular dynamic
Vascular myocytes
Journal
Biochemical pharmacology
ISSN: 1873-2968
Titre abrégé: Biochem Pharmacol
Pays: England
ID NLM: 0101032
Informations de publication
Date de publication:
09 2022
09 2022
Historique:
received:
29
04
2022
revised:
07
07
2022
accepted:
02
08
2022
pubmed:
9
8
2022
medline:
25
8
2022
entrez:
8
8
2022
Statut:
ppublish
Résumé
Mdivi-1 is widely used as a pharmacological tool to inhibit dynamin-related protein-1-mediated mitochondrial fission. Whether this compound may interact directly or indirectly with ion channels or cellular pathways fundamental for the regulation of vascular smooth muscle tone remains unknown. The present study aimed to assess the effect of mdivi-1 on Ca
Identifiants
pubmed: 35940257
pii: S0006-2952(22)00299-4
doi: 10.1016/j.bcp.2022.115205
pii:
doi:
Substances chimiques
3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone
0
Ion Channels
0
Quinazolinones
0
Vasodilator Agents
0
Phenylephrine
1WS297W6MV
Death-Associated Protein Kinases
EC 2.7.11.1
Dynamins
EC 3.6.5.5
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
115205Informations de copyright
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