Digit ratio (2D:4D) and maternal testosterone-to-estradiol ratio measured in early pregnancy.

Androgens / analysis Child Digit Ratios Estradiol Female Fingers / anatomy & histology Gonadal Steroid Hormones Humans Pregnancy Testosterone / analysis

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
09 08 2022
Historique:
received: 08 02 2022
accepted: 22 07 2022
entrez: 9 8 2022
pubmed: 10 8 2022
medline: 12 8 2022
Statut: epublish

Résumé

The ratio of index to ring finger (2D:4D) has been hypothesised to indicate prenatal androgen exposure, yet evidence for its validity is lacking. We report the first pre-registered study to investigate mothers' early pregnancy sex hormone concentrations in relation to their children's digit ratios measured at 18-22-month follow-up. Although the testosterone (T) to estradiol (E) ratio correlated negatively with right hand digit ratio (R2D:4D) and directional asymmetry (right-minus-left) in digit ratio (D

Identifiants

DOI: 10.1038/s41598-022-17247-3 PMID: 35945232 PMC: PMC9363442
pubmed: 35945232
doi: 10.1038/s41598-022-17247-3
pii: 10.1038/s41598-022-17247-3
pmc: PMC9363442
doi:

Substances chimiques

Androgens 0
Gonadal Steroid Hormones 0
Testosterone 3XMK78S47O
Estradiol 4TI98Z838E

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

13586

Subventions

Organisme : Wellcome Trust
ID : 214322\Z\18\Z
Pays : United Kingdom
Organisme : Medical Research Council
Pays : United Kingdom
Organisme : Department of Health
Pays : United Kingdom

Informations de copyright

© 2022. The Author(s).

Références

J Clin Invest. 2002 Apr;109(7):973-81
pubmed: 11927624
Early Hum Dev. 2017 Oct;113:71-72
pubmed: 28807670
Early Hum Dev. 2017 Oct;113:73-74
pubmed: 28927753
Early Hum Dev. 2006 Jul;82(7):469-75
pubmed: 16473482
Hum Reprod. 2003 May;18(5):976-9
pubmed: 12721171
Horm Behav. 2011 Aug;60(3):256-63
pubmed: 21664359
Early Hum Dev. 2002 Dec;70(1-2):47-54
pubmed: 12441204
Arch Sex Behav. 2012 Jun;41(3):711-24
pubmed: 22270254
Horm Behav. 2021 Feb;128:104908
pubmed: 33279508
J Biosoc Sci. 1995 Jul;27(3):359-68
pubmed: 7650053
Early Hum Dev. 2022 Jan;164:105521
pubmed: 34922146
Child Dev. 2002 Nov-Dec;73(6):1678-87
pubmed: 12487486
J Biosoc Sci. 2022 Jan 28;:1-13
pubmed: 35088686
J Dev Orig Health Dis. 2021 Dec;12(6):923-932
pubmed: 33336644
Early Hum Dev. 2013 Feb;89(2):107-12
pubmed: 23017880
Early Hum Dev. 2018 Dec;127:28-32
pubmed: 30223207
Twin Res Hum Genet. 2006 Apr;9(2):215-9
pubmed: 16611491
Endocrinology. 2009 Nov;150(11):5119-24
pubmed: 19819951
Clin Endocrinol (Oxf). 2007 Nov;67(5):743-7
pubmed: 17634075
Int J Androl. 2003 Apr;26(2):76-83
pubmed: 12641825
Psicothema. 2009 Aug;21(3):382-9
pubmed: 19622317
Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16289-94
pubmed: 21896736
Twin Res Hum Genet. 2008 Jun;11(3):335-41
pubmed: 18498211
Neurosci Biobehav Rev. 2020 Jan;108:322-340
pubmed: 31711815
J Neurosci Res. 2020 Feb;98(2):353-370
pubmed: 31359506
Mol Autism. 2015 Dec 28;6:68
pubmed: 26715984
Psychol Rep. 2007 Feb;100(1):115-26
pubmed: 17451014
Arch Sex Behav. 2009 Feb;38(1):143-8
pubmed: 17653838
Psychoneuroendocrinology. 2010 Sep;35(8):1235-44
pubmed: 20299156
Horm Behav. 2021 Mar;129:104929
pubmed: 33454315
PLoS One. 2015 Mar 06;10(3):e0120636
pubmed: 25746668
Horm Res. 1994;42(3):106-9
pubmed: 7995613
Clin Psychopharmacol Neurosci. 2021 Feb 28;19(1):26-45
pubmed: 33508786
Arch Sex Behav. 2009 Apr;38(2):298-305
pubmed: 18340520
Arch Sex Behav. 2008 Feb;37(1):112-8
pubmed: 18074216
J Steroid Biochem Mol Biol. 1991 Jul;39(1):51-4
pubmed: 2069866
Behav Genet. 1998 May;28(3):165-71
pubmed: 9670592
Am J Hum Biol. 2009 Mar-Apr;21(2):188-91
pubmed: 18988284
Acta Obstet Gynecol Scand. 1999 May;78(5):367-71
pubmed: 10326878
Horm Behav. 2022 Apr;140:105125
pubmed: 35131524
Andrology. 2013 Jan;1(1):94-9
pubmed: 23258636
Horm Behav. 2020 Nov;126:104867
pubmed: 32998030
Am J Hum Biol. 2022 Mar;34(3):e23657
pubmed: 34331730
Early Hum Dev. 2015 Feb;91(2):111-7
pubmed: 25594498
Early Hum Dev. 2004 Apr;77(1-2):23-8
pubmed: 15113628
Hum Reprod. 1998 Nov;13(11):3000-4
pubmed: 9853845
Front Endocrinol (Lausanne). 2014 May 02;5:64
pubmed: 24829559
Am J Phys Anthropol. 2006 Jan;129(1):143-50
pubmed: 16224778
Am J Obstet Gynecol. 1978 May 1;131(1):60-2
pubmed: 645784
Horm Behav. 2006 Mar;49(3):315-9
pubmed: 16143332
Front Endocrinol (Lausanne). 2013 Dec 05;4:185
pubmed: 24367354
Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16143-4
pubmed: 21930921
J Dev Orig Health Dis. 2021 Dec;12(6):859-864
pubmed: 33472723
Mol Autism. 2021 Jul 8;12(1):51
pubmed: 34238355
Horm Behav. 2004 Dec;46(5):663-9
pubmed: 15555509
Psychol Sci. 2011 Nov;22(11):1359-66
pubmed: 22006061
Early Hum Dev. 2021 Jan;152:105273
pubmed: 33227633
Proc Biol Sci. 2020 Dec 23;287(1941):20201756
pubmed: 33352071
Dev Psychobiol. 2020 Nov;62(7):979-991
pubmed: 31372988
Sci Rep. 2021 May 26;11(1):10998
pubmed: 34040007
Biol Sex Differ. 2017 Apr 12;8:11
pubmed: 28413602
Neuroimage. 2006 Nov 1;33(2):522-30
pubmed: 16938470
Prenat Diagn. 2010 Aug;30(8):806-7
pubmed: 20661893
Horm Behav. 2002 Dec;42(4):380-6
pubmed: 12488105
J Dev Orig Health Dis. 2019 Jun;10(3):362-367
pubmed: 30376903
Early Hum Dev. 2002 Jun;68(1):21-6
pubmed: 12191526
Oman Med J. 2012 Nov;27(6):471-4
pubmed: 23226817
Steroids. 2016 Sep;113:46-51
pubmed: 27343975
J Clin Endocrinol Metab. 2015 Mar;100(3):E508-17
pubmed: 25514102
PLoS One. 2021 Oct 4;16(10):e0258179
pubmed: 34606496
Proc Biol Sci. 2015 Oct 7;282(1816):20151351
pubmed: 26400740
Am J Hum Biol. 2010 Sep-Oct;22(5):619-30
pubmed: 20737609
Endocrinology. 2009 Nov;150(11):4819-22
pubmed: 19846613
J Clin Endocrinol Metab. 2010 Dec;95(12):5305-13
pubmed: 20826578
Am J Hum Biol. 2009 May-Jun;21(3):365-70
pubmed: 19263413
Arch Sex Behav. 2005 Jun;34(3):329-33
pubmed: 15971015
Front Endocrinol (Lausanne). 2014 Jan 30;5:9
pubmed: 24523714
Prenat Diagn. 1985 May-Jun;5(3):175-81
pubmed: 4022941
Arch Sex Behav. 2010 Feb;39(1):57-62
pubmed: 19301112

Auteurs

Gareth Richards (G)

School of Psychology, Faculty of Medical Sciences, Newcastle University, 4.32 Dame Margaret Barbour Building, Wallace Street, Newcastle upon Tyne, UK. gareth.richards@ncl.ac.uk.

Ezra Aydin (E)

Department of Psychology, University of Cambridge, Cambridge, UK.
Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA.

Alex Tsompanidis (A)

Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK.

Eglė Padaigaitė (E)

Wolfson Centre for Young People's Mental Health, Cardiff University, Cardiff, UK.

Topun Austin (T)

The Rosie Hospital, Cambridge University Hospitals Foundation Trust, Cambridge, UK.
NIHR Cambridge Biomedical Research Centre, Cambridge, UK.

Carrie Allison (C)

Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK.

Rosemary Holt (R)

Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK.

Simon Baron-Cohen (S)

Autism Research Centre, Department of Psychiatry, University of Cambridge, Cambridge, UK.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hormones, substituts d'hormones et antagonistes d'hormones › Hormones › Androgènes › Digit ratio (2D:4D) and maternal...
questionsmedicales.fr › Personnes › Tranches d'âge › Enfant › Digit ratio (2D:4D) and maternal...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Biométrie › Anthropométrie › Ratios digitaux › Digit ratio (2D:4D) and maternal...
questionsmedicales.fr › Hormones gonadiques › Hormones sexuelles stéroïdiennes › Congénères de l'oestradiol › Oestradiol › Digit ratio (2D:4D) and maternal...
questionsmedicales.fr › Régions du corps › Membres › Membre supérieur › Main › Doigts › Digit ratio (2D:4D) and maternal...
questionsmedicales.fr › Hormones gonadiques › Hormones sexuelles stéroïdiennes › Digit ratio (2D:4D) and maternal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Digit ratio (2D:4D) and maternal...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Digit ratio (2D:4D) and maternal...
questionsmedicales.fr › Hormones gonadiques › Hormones sexuelles stéroïdiennes › Congénères de la testostérone › Testostérone › Digit ratio (2D:4D) and maternal...