Multitargeting the Action of 5-HT
5-HT6 ligands
Alzheimer’s disease
CDK5
MARK4
ROCKI
ROCKII
dementia
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
07 Aug 2022
07 Aug 2022
Historique:
received:
20
07
2022
revised:
03
08
2022
accepted:
05
08
2022
entrez:
12
8
2022
pubmed:
13
8
2022
medline:
16
8
2022
Statut:
epublish
Résumé
In view of the unsatisfactory treatment of cognitive disorders, in particular Alzheimer's disease (AD), the aim of this review was to perform a computer-aided analysis of the state of the art that will help in the search for innovative polypharmacology-based therapeutic approaches to fight against AD. Apart from 20-year unrenewed cholinesterase- or NMDA-based AD therapy, the hope of effectively treating Alzheimer's disease has been placed on serotonin 5-HT
Identifiants
pubmed: 35955902
pii: ijms23158768
doi: 10.3390/ijms23158768
pmc: PMC9368844
pii:
doi:
Substances chimiques
Ligands
0
Receptors, Serotonin
0
Serotonin Antagonists
0
Serotonin
333DO1RDJY
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Science Center
ID : UMO-2018/31/B/NZ7/02160
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