Selective Integrin α
DNA nanotechnology
integrins
multivalency
selective targeting
spatial tolerance
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
04 Aug 2022
04 Aug 2022
Historique:
received:
30
06
2022
revised:
29
07
2022
accepted:
02
08
2022
entrez:
12
8
2022
pubmed:
13
8
2022
medline:
16
8
2022
Statut:
epublish
Résumé
Targeting cells specifically based on receptor expression levels remains an area of active research to date. Selective binding of receptors cannot be achieved by increasing the individual binding strength, as this does not account for differing distributions of receptor density across healthy and diseased cells. Engaging receptors above a threshold concentration would be desirable in devising selective diagnostics. Integrins are prime target candidates as they are readily available on the cell surface and have been reported to be overexpressed in diseases. Insights into their spatial organization would therefore be advantageous to design selective targeting agents. Here, we investigated the effect of activation method on integrin α
Identifiants
pubmed: 35956918
pii: molecules27154968
doi: 10.3390/molecules27154968
pmc: PMC9370198
pii:
doi:
Substances chimiques
Integrin alpha5beta1
0
Integrins
0
Ligands
0
DNA
9007-49-2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Swiss National Science Foundation
ID : PCEGP2_181137
Pays : Switzerland
Organisme : Volkswagen Stiftung "Life?
ID : 98200
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