Bacterial degrons in synthetic circuits.
degradation
oscillatory circuits
proteases
queueing theory
Journal
Open biology
ISSN: 2046-2441
Titre abrégé: Open Biol
Pays: England
ID NLM: 101580419
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
entrez:
17
8
2022
pubmed:
18
8
2022
medline:
19
8
2022
Statut:
ppublish
Résumé
Bacterial proteases are a promising post-translational regulation strategy in synthetic circuits because they recognize specific amino acid degradation tags (degrons) that can be fine-tuned to modulate the degradation levels of tagged proteins. For this reason, recent efforts have been made in the search for new degrons. Here we review the up-to-date applications of degradation tags for circuit engineering in bacteria. In particular, we pay special attention to the effects of degradation bottlenecks in synthetic oscillators and introduce mathematical approaches to study queueing that enable the quantitative modelling of proteolytic queues.
Identifiants
pubmed: 35975648
doi: 10.1098/rsob.220180
pmc: PMC9382460
doi:
Substances chimiques
Peptide Hydrolases
EC 3.4.-
Types de publication
Journal Article
Review
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
220180Subventions
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
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