Virenscarotins A-M, thirteen undescribed carotane sesquiterpenes from the fungus Trichoderma virens.
Absolute configurations
Biological activity
Carotane sesquiterpenes
Hypocreaceae
Trichoderma virens
Journal
Phytochemistry
ISSN: 1873-3700
Titre abrégé: Phytochemistry
Pays: England
ID NLM: 0151434
Informations de publication
Date de publication:
Nov 2022
Nov 2022
Historique:
received:
24
05
2022
revised:
01
08
2022
accepted:
02
08
2022
pubmed:
18
8
2022
medline:
12
10
2022
entrez:
17
8
2022
Statut:
ppublish
Résumé
A document investigation on the fungus Trichoderma virens led to the isolation of thirteen undescribed carotane sesquiterpenes and homologous. All structures were elucidated on the basis of NMR and HRESIMS data, and their absolute configurations were assigned by ECD calculation. Especially, virenscarotins A and B were first ramifications forged by aldol condensation of 4-hydroxy-3-isopentenyl-benzaldehyde with two hydroxyl groups in ring A of traditional carotane sesquiterpenes. Ring rearrangement/expansion and oxidative cleavage of normal carotane sesquiterpenes lead to the six-membered ring A of compound virenscarotin C and the ring A cleavage of compound virenscarotin D. All compounds were evaluated for cytotoxic, anti-inflammatory, and seed germination inhibitory activities.
Identifiants
pubmed: 35977601
pii: S0031-9422(22)00284-9
doi: 10.1016/j.phytochem.2022.113368
pii:
doi:
Substances chimiques
Benzaldehydes
0
Sesquiterpenes
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
113368Informations de copyright
Copyright © 2022 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.