Interleukin-33: Metabolic checkpoints, metabolic processes, and epigenetic regulation in immune cells.
IL-33
epigenetics
immune cells
metabolic checkpoints
metabolic pathways
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
21
03
2022
accepted:
12
07
2022
entrez:
18
8
2022
pubmed:
19
8
2022
medline:
20
8
2022
Statut:
epublish
Résumé
Interleukin-33 (IL-33) is a pleiotropic cytokine linked to various immune cells in the innate and adaptive immune systems. Recent studies of the effects of IL-33 on immune cells are beginning to reveal its regulatory mechanisms at the levels of cellular metabolism and epigenetic modifications. In response to IL-33 stimulation, these programs are intertwined with transcriptional programs, ultimately determining the fate of immune cells. Understanding these specific molecular events will help to explain the complex role of IL-33 in immune cells, thereby guiding the development of new strategies for immune intervention. Here, we highlight recent findings that reveal how IL-33, acting as an intracellular nuclear factor or an extracellular cytokine, alters metabolic checkpoints and cellular metabolism, which coordinately contribute to cell growth and function. We also discuss recent studies supporting the role of IL-33 in epigenetic alterations and speculate about the mechanisms underlying this relationship.
Identifiants
pubmed: 35979357
doi: 10.3389/fimmu.2022.900826
pmc: PMC9376228
doi:
Substances chimiques
Cytokines
0
Interleukin-33
0
Types de publication
Journal Article
Review
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
900826Informations de copyright
Copyright © 2022 Lin, Liu, Ma, Hao, Liang, Zhao, Zhang, Meng and Lu.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
J Exp Med. 2021 Feb 1;218(2):
pubmed: 33104171
Nat Rev Cancer. 2020 Feb;20(2):74-88
pubmed: 31686003
Immunity. 2018 Feb 20;48(2):258-270.e5
pubmed: 29452935
J Immunol. 2016 Oct 1;197(7):2909-17
pubmed: 27559047
Front Immunol. 2021 May 19;12:687192
pubmed: 34093589
Nat Rev Immunol. 2016 Feb;16(2):112-23
pubmed: 26806484
FEBS Lett. 2017 Oct;591(19):3089-3103
pubmed: 28600802
Genes Dev. 2008 Nov 1;22(21):2980-93
pubmed: 18981476
J Immunol. 2022 Feb 1;208(3):732-744
pubmed: 34996839
Int Immunol. 2008 Aug;20(8):1019-30
pubmed: 18550585
Nat Commun. 2020 Sep 22;11(1):4786
pubmed: 32963227
Nat Immunol. 2016 Feb;17(2):122-31
pubmed: 26784265
Cancer Biol Med. 2021 Feb 15;18(1):172-183
pubmed: 33628592
Immunol Rev. 2017 Jul;278(1):173-184
pubmed: 28658560
Nat Commun. 2021 May 5;12(1):2538
pubmed: 33953160
Immunity. 2021 Nov 9;54(11):2531-2546.e5
pubmed: 34644537
Nat Rev Immunol. 2019 May;19(5):282-290
pubmed: 30808985
Immunol Rev. 2012 Sep;249(1):43-58
pubmed: 22889214
Nat Immunol. 2013 Oct;14(10):1007-13
pubmed: 24048122
Cell Res. 2020 Aug;30(8):649-659
pubmed: 32709897
Nat Rev Immunol. 2019 May;19(5):291-304
pubmed: 30679807
Curr Opin Immunol. 2014 Dec;31:31-7
pubmed: 25278425
J Immunol. 2015 May 15;194(10):4777-83
pubmed: 25870243
J Allergy Clin Immunol. 2020 Feb;145(2):502-517.e5
pubmed: 31738991
Nat Cell Biol. 2017 Nov;19(11):1298-1306
pubmed: 29058720
Immunity. 2015 Mar 17;42(3):419-30
pubmed: 25786174
Proc Natl Acad Sci U S A. 2020 Mar 17;117(11):6047-6055
pubmed: 32123114
Cytokine Growth Factor Rev. 2019 Dec;50:60-74
pubmed: 31085085
Nat Immunol. 2015 Mar;16(3):276-85
pubmed: 25599561
J Endocrinol. 2016 Oct;231(1):35-48
pubmed: 27562191
Nat Immunol. 2021 Nov;22(11):1367-1374
pubmed: 34686862
Immunobiology. 2016 Mar;221(3):412-7
pubmed: 26688508
Amino Acids. 2009 May;37(1):153-68
pubmed: 19030957
Immunity. 2017 Nov 21;47(5):928-942.e7
pubmed: 29166590
Immunity. 2015 Oct 20;43(4):690-702
pubmed: 26410627
J Immunol. 2015 Jun 15;194(12):5948-52
pubmed: 25926677
Oncoimmunology. 2015 Jun 24;5(1):e1063772
pubmed: 26942079
Front Immunol. 2017 Apr 24;8:475
pubmed: 28484466
Mucosal Immunol. 2021 May;14(3):585-593
pubmed: 33106586
Immunity. 2020 Apr 14;52(4):620-634.e6
pubmed: 32268121
Nat Cell Biol. 2011 Aug 28;13(10):1272-9
pubmed: 21968997
Clin Transl Immunology. 2020 Jun 17;9(6):e1146
pubmed: 32566227
Nat Rev Immunol. 2010 Feb;10(2):103-10
pubmed: 20081870
Immunity. 2020 May 19;52(5):782-793.e5
pubmed: 32272082
Nat Commun. 2018 May 29;9(1):2095
pubmed: 29844370
Front Immunol. 2019 Mar 20;10:522
pubmed: 30949175
Annu Rev Immunol. 2006;24:607-56
pubmed: 16551261
Immunity. 2015 Feb 17;42(2):294-308
pubmed: 25692703
Cell Metab. 2017 Jun 6;25(6):1282-1293.e7
pubmed: 28416194
Nat Rev Immunol. 2012 Apr 20;12(5):325-38
pubmed: 22517423
Sci Immunol. 2017 Mar 10;2(9):
pubmed: 28783701
Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E219-27
pubmed: 17389706
J Immunol. 2019 Feb 1;202(3):943-955
pubmed: 30635396
Nat Immunol. 2014 Aug;15(8):749-757
pubmed: 24973821
Science. 2017 May 5;356(6337):513-519
pubmed: 28473584
Immunology. 2022 Jan;165(1):61-73
pubmed: 34411293
J Allergy Clin Immunol. 2012 Nov;130(5):1159-1166.e6
pubmed: 22738676
J Immunol. 2011 Aug 15;187(4):1609-16
pubmed: 21734074
Immunity. 2017 May 16;46(5):714-729
pubmed: 28514673
Nat Immunol. 2020 Jan;21(1):75-85
pubmed: 31844326
Nat Rev Cancer. 2020 Oct;20(10):594-607
pubmed: 32678342
Nat Immunol. 2016 Dec;17(12):1459-1466
pubmed: 27695003
Front Immunol. 2021 Apr 22;12:671966
pubmed: 33968080
Nat Immunol. 2016 Jun;17(6):656-65
pubmed: 27043409
Nat Immunol. 2017 Oct;18(10):1160-1172
pubmed: 28783152
Nat Metab. 2019 Mar;1(3):321-333
pubmed: 32694720
PLoS One. 2008 Oct 06;3(10):e3331
pubmed: 18836528
Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):4056-61
pubmed: 25829541
Cold Spring Harb Perspect Biol. 2015 Aug 03;7(8):a019141
pubmed: 26238356
Nature. 2019 Jul;571(7766):489-499
pubmed: 31341302
Eur J Immunol. 2015 Nov;45(11):3034-44
pubmed: 26256265
J Clin Invest. 2020 Oct 1;130(10):5397-5412
pubmed: 32644975
Science. 2009 Feb 6;323(5915):793-7
pubmed: 19131594
J Exp Med. 2017 Oct 2;214(10):3015-3035
pubmed: 28798029
Immunity. 2009 Jun 19;30(6):832-44
pubmed: 19538929
Mucosal Immunol. 2021 Mar;14(2):468-478
pubmed: 32811992
Cell Res. 2020 Apr;30(4):328-342
pubmed: 32203134
J Immunol. 2009 Sep 15;183(6):3642-51
pubmed: 19717524
Front Immunol. 2021 Jun 29;12:702580
pubmed: 34267763
Curr Opin Immunol. 2016 Oct;42:16-24
pubmed: 27254379
Immunity. 2015 Jun 16;42(6):1005-19
pubmed: 26084021
Immunity. 2016 Feb 16;44(2):355-67
pubmed: 26872699
J Immunol. 2016 Nov 1;197(9):3662-3668
pubmed: 27694493
Nat Rev Immunol. 2015 Dec;15(12):731-44
pubmed: 26603899
Front Immunol. 2019 Feb 01;10:127
pubmed: 30774633
Int Immunopharmacol. 2021 Dec;101(Pt A):108209
pubmed: 34624652
Cell. 2016 Jun 30;166(1):63-76
pubmed: 27293185
Proc Natl Acad Sci U S A. 2007 Jan 2;104(1):282-7
pubmed: 17185418
Immunol Rev. 2010 Nov;238(1):233-46
pubmed: 20969596
Nat Rev Immunol. 2017 Dec;17(12):746-760
pubmed: 28891557
J Immunol. 2011 Mar 15;186(6):3299-303
pubmed: 21317389
Nat Rev Immunol. 2016 Sep;16(9):553-65
pubmed: 27396447
Immunity. 2018 Mar 20;48(3):542-555.e6
pubmed: 29523440
Cell Mol Immunol. 2020 Dec;17(12):1266-1268
pubmed: 32139884
Physiol Rev. 2018 Apr 1;98(2):641-665
pubmed: 29412048
Science. 2015 May 22;348(6237):aaa6566
pubmed: 25999512
Immunity. 2011 Aug 26;35(2):299-311
pubmed: 21867929
Front Immunol. 2018 Nov 13;9:2601
pubmed: 30483263
Proc Natl Acad Sci U S A. 2015 Aug 25;112(34):10762-7
pubmed: 26243875
Nat Rev Immunol. 2021 Nov;21(11):718-738
pubmed: 33981085
Front Immunol. 2021 May 03;12:654225
pubmed: 34093543
Science. 2012 Feb 24;335(6071):984-9
pubmed: 22323740
Nat Rev Nephrol. 2021 Jul;17(7):465-480
pubmed: 33828286
J Immunol. 2006 Mar 15;176(6):3470-9
pubmed: 16517715
Nat Immunol. 2021 Aug;22(8):1042-1051
pubmed: 34267375
Nat Rev Immunol. 2010 Jun;10(6):440-52
pubmed: 20498670
Nat Rev Immunol. 2016 Nov;16(11):676-689
pubmed: 27640624
Nat Immunol. 2020 Sep;21(9):998-1009
pubmed: 32747815
Front Immunol. 2018 Dec 18;9:3026
pubmed: 30619366
Cancer Res. 2015 Jan 15;75(2):275-83
pubmed: 25406192
JCI Insight. 2021 Jan 11;6(1):
pubmed: 33427206
J Mol Cell Cardiol. 2017 Feb;103:22-30
pubmed: 28041873
Eur J Immunol. 2016 Jan;46(1):13-21
pubmed: 26643360
Nat Rev Mol Cell Biol. 2018 Feb;19(2):121-135
pubmed: 28974774
Science. 2009 Jun 26;324(5935):1713-6
pubmed: 19556508
J Allergy Clin Immunol. 2022 Jun;149(6):2091-2104
pubmed: 34974065
Front Immunol. 2018 Feb 19;9:270
pubmed: 29520272
Nat Immunol. 2015 Aug;16(8):838-849
pubmed: 26147685
Epigenetics. 2009 Feb 16;4(2):85-8
pubmed: 19384057
BMC Immunol. 2010 Oct 19;11:52
pubmed: 20958987
Trends Immunol. 2016 May;37(5):321-333
pubmed: 27055914
Nature. 2014 Sep 25;513(7519):564-568
pubmed: 25043027
Nat Rev Immunol. 2019 Jun;19(6):369-382
pubmed: 30718830
Front Immunol. 2017 Feb 07;8:93
pubmed: 28223985