Cadmium selenide sulfide quantum dots with tuneable emission profiles: An electrochemiluminescence platform for the determination of TIMP-1 protein.

Biosensing Techniques Cadmium Compounds Electrochemical Techniques Immunoassay Luminescent Measurements Quantum Dots Selenium Compounds Sulfides Tissue Inhibitor of Metalloproteinase-1
CdSeS Electrochemiluminescence Nanoparticle Point of care biosensing TIMP 1 protein Tuneable emission

Journal

Bioelectrochemistry (Amsterdam, Netherlands)
ISSN: 1878-562X
Titre abrégé: Bioelectrochemistry
Pays: Netherlands
ID NLM: 100953583

Informations de publication

Date de publication:
Dec 2022
Historique:
received: 29 04 2022
revised: 28 07 2022
accepted: 29 07 2022
pubmed: 23 8 2022
medline: 19 10 2022
entrez: 22 8 2022
Statut: ppublish

Résumé

The development of electrochemiluminescent (ECL) luminophores with tuneable emission profiles is a key requirement in the development of multi-analyte ECL sensing platforms. This study presents the first reported use of cadmium selenide sulfide (CdSeS) quantum dots (QDs) as ECL emitters in which both the ECL emission profile and cathodic potential can be tailored by alteration of the Se/S ratio. CdSeS QDs were synthesised using an aqueous synthetic route thereby avoiding the use of organic reagents, high temperatures and inert gasses. The suitability of the CdSeS QDs to ECL sensing applications is demonstrated via the quantitative determination of TIMP-1 protein at clinically relevant concentrations. The developed cathodic ECL immunosensor exhibited a detectable linear range of 6-60 ng/mL and a limit of detection (LOD) of 1.54 ng/mL. TIMP-1 protein plays a crucial role in pregnancy, wound healing, and cancer prognosis.

Identifiants

DOI: 10.1016/j.bioelechem.2022.108221 PMID: 35994902
pubmed: 35994902
pii: S1567-5394(22)00172-4
doi: 10.1016/j.bioelechem.2022.108221
pii:
doi:

Substances chimiques

Cadmium Compounds 0
Selenium Compounds 0
Sulfides 0
Tissue Inhibitor of Metalloproteinase-1 0
cadmium selenide A7F646JC5C

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

108221

Informations de copyright

Copyright © 2022 Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: The authors declare that there are no known competing financial interests or personal relationships that could have appeared to influence the work in this paper. The Irish Research Council Grant GOI 2018/1772 funded this work.

Auteurs

Siobhán O'Connor (S)

Bernal Institute, University of Limerick, Castletroy, Limerick, Ireland.

Luluh Al Hassan (L)

Bernal Institute, University of Limerick, Castletroy, Limerick, Ireland.

Grace Brennan (G)

Bernal Institute, University of Limerick, Castletroy, Limerick, Ireland.

Kieran McCarthy (K)

Bernal Institute, University of Limerick, Castletroy, Limerick, Ireland.

Christophe Silien (C)

Bernal Institute, University of Limerick, Castletroy, Limerick, Ireland.

Ning Liu (N)

Bernal Institute, University of Limerick, Castletroy, Limerick, Ireland.

Tadhg Kennedy (T)

Bernal Institute, University of Limerick, Castletroy, Limerick, Ireland.

Kevin Ryan (K)

Bernal Institute, University of Limerick, Castletroy, Limerick, Ireland.

Emmet O'Reilly (E)

Bernal Institute, University of Limerick, Castletroy, Limerick, Ireland. Electronic address: emmet.oreilly@ul.ie.

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Classifications MeSH

questionsmedicales.fr › Techniques d'investigation › Techniques de sonde moléculaire › Techniques de biocapteur › Cadmium selenide sulfide quantum dots with...
questionsmedicales.fr › Produits chimiques inorganiques › Composés du cadmium › Cadmium selenide sulfide quantum dots with...
questionsmedicales.fr › Techniques d'investigation › Techniques électrochimiques › Cadmium selenide sulfide quantum dots with...
questionsmedicales.fr › Techniques d'investigation › Techniques de sonde moléculaire › Dosage immunologique › Cadmium selenide sulfide quantum dots with...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Photométrie › Mesures de luminescence › Cadmium selenide sulfide quantum dots with...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › Boîtes quantiques › Cadmium selenide sulfide quantum dots with...
questionsmedicales.fr › Produits chimiques inorganiques › Composés du sélénium › Cadmium selenide sulfide quantum dots with...
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Sulfures › Cadmium selenide sulfide quantum dots with...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines sécrétoires inhibitrices de protéinases › Inhibiteur tissulaire des métalloprotéinases › Inhibiteur tissulaire de métalloprotéinase-1 › Cadmium selenide sulfide quantum dots with...