Direct Synthesis of 3-Aryl Substituted Isocoumarins and Phthalides through Palladium Acetate Catalyzed C(sp
C−H activation
benzylidenephthalide
ionic liquid
isocoumarin
palladium catalysis
Journal
Chemistry (Weinheim an der Bergstrasse, Germany)
ISSN: 1521-3765
Titre abrégé: Chemistry
Pays: Germany
ID NLM: 9513783
Informations de publication
Date de publication:
21 Nov 2022
21 Nov 2022
Historique:
received:
28
07
2022
pubmed:
24
8
2022
medline:
24
11
2022
entrez:
23
8
2022
Statut:
ppublish
Résumé
A novel Pd-catalysed oxidative coupling between benzoic acids and vinylarenes or acrylates to furnish isocoumarins and phthalides is reported. The reaction proceeds smoothly in molten tetrabutylammonium acetate via a selective C-H bond activation, with very low percentage of ligand-free palladium acetate as the catalyst, under atmospheric pressure of oxygen. Sub-stoichiometric amount of copper acetate is also required as a reoxidant for the palladium.
Identifiants
pubmed: 35997238
doi: 10.1002/chem.202202350
pmc: PMC9826210
doi:
Substances chimiques
Palladium
5TWQ1V240M
Isocoumarins
0
phthalide
8VV922U86J
Ionic Liquids
0
Acetates
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e202202350Subventions
Organisme : Ministero dell'Istruzione, dell'Università e della Ricerca
ID : ECOTEC _ARS 01_00951
Informations de copyright
© 2022 The Authors. Chemistry - A European Journal published by Wiley-VCH GmbH.
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