Serotonin 5-HT
Acetylcholinesterase
/ metabolism
Alzheimer Disease
/ drug therapy
Amyloid beta-Peptides
/ metabolism
Antioxidants
/ chemistry
Butyrylcholinesterase
/ metabolism
Chelating Agents
/ chemistry
Cholinesterase Inhibitors
/ chemistry
Drug Design
Humans
Ligands
Receptors, Serotonin
/ metabolism
Serotonin
Structure-Activity Relationship
5-HT6 receptor ligands
AChE
Alzheimer’s disease
BuChE
antioxidant properties
cholinesterase inhibitors
metal-chelating properties
multifunctional ligands
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
21 Aug 2022
21 Aug 2022
Historique:
received:
08
08
2022
revised:
18
08
2022
accepted:
20
08
2022
entrez:
26
8
2022
pubmed:
27
8
2022
medline:
30
8
2022
Statut:
epublish
Résumé
Neurodegeneration leading to Alzheimer's disease results from a complex interplay of a variety of processes including misfolding and aggregation of amyloid beta and tau proteins, neuroinflammation or oxidative stress. Therefore, to address more than one of these, drug discovery programmes focus on the development of multifunctional ligands, preferably with disease-modifying and symptoms-reducing potential. Following this idea, herein we present the design and synthesis of multifunctional ligands and biological evaluation of their 5-HT
Identifiants
pubmed: 36012707
pii: ijms23169443
doi: 10.3390/ijms23169443
pmc: PMC9409043
pii:
doi:
Substances chimiques
Amyloid beta-Peptides
0
Antioxidants
0
Chelating Agents
0
Cholinesterase Inhibitors
0
Ligands
0
Receptors, Serotonin
0
serotonin 6 receptor
0
Serotonin
333DO1RDJY
Acetylcholinesterase
EC 3.1.1.7
Butyrylcholinesterase
EC 3.1.1.8
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Science Center
ID : 2016/23/D/NZ7/01328
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