Quality control mechanisms that protect nuclear envelope identity and function.
Journal
The Journal of cell biology
ISSN: 1540-8140
Titre abrégé: J Cell Biol
Pays: United States
ID NLM: 0375356
Informations de publication
Date de publication:
05 09 2022
05 09 2022
Historique:
received:
25
05
2022
revised:
08
08
2022
accepted:
10
08
2022
entrez:
29
8
2022
pubmed:
30
8
2022
medline:
1
9
2022
Statut:
ppublish
Résumé
The nuclear envelope (NE) is a specialization of the endoplasmic reticulum with distinct biochemistry that defines inner and outer membranes connected at a pore membrane that houses nuclear pore complexes (NPCs). Quality control mechanisms that maintain the physical integrity and biochemical identity of these membranes are critical to ensure that the NE acts as a selective barrier that also contributes to genome stability and metabolism. As the proteome of the NE is highly integrated, it is challenging to turn over by conventional ubiquitin-proteasome and autophagy mechanisms. Further, removal of entire sections of the NE requires elaborate membrane remodeling that is poorly understood. Nonetheless, recent work has made inroads into discovering specializations of cellular degradative machineries tailored to meeting the unique challenges imposed by the NE. In addition, cells have evolved mechanisms to surveil and repair the NE barrier to protect against the deleterious effects of a breach in NE integrity, in the form of either a ruptured NE or a dysfunctional NPC. Here, we synthesize the most recent work exploring NE quality control mechanisms across eukaryotes.
Identifiants
pubmed: 36036741
pii: 213424
doi: 10.1083/jcb.202205123
pmc: PMC9442147
pii:
doi:
Substances chimiques
Nuclear Pore Complex Proteins
0
Ubiquitin
0
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM105672
Pays : United States
Organisme : NIA NIH HHS
ID : F31 AG069490
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS122236
Pays : United States
Informations de copyright
© 2022 Mannino and Lusk.
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