[A new cyclopeptide from Selaginella tamariscina].

Chromatography, High Pressure Liquid Magnetic Resonance Spectroscopy Molecular Structure Peptides, Cyclic / pharmacology Selaginellaceae / chemistry
Selaginella tamariscina cyclopeptide cytotoxicity selapeptin A structural identification

Journal

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
ISSN: 1001-5302
Titre abrégé: Zhongguo Zhong Yao Za Zhi
Pays: China
ID NLM: 8913656

Informations de publication

Date de publication:
Aug 2022
Historique:
entrez: 1 9 2022
pubmed: 2 9 2022
medline: 9 9 2022
Statut: ppublish

Résumé

One new cyclopeptide was isolated from the ethyl acetate fraction of the 75% EtOH extract of Selaginella tamariscina by various column chromatography methods(HP-20, polyamide and semi-preparative HPLC). Its structure was identified as selapeptin A(1) by extensive spectroscopic analysis(HR-ESI-MS, 1 D and 2 D NMR). Compound 1 was evaluated for cytotoxic activities by MTT assay. It showed potent cytotoxic activity against B16 F10 with the inhibition rate of 51.57%±4.34% at 40 μmol·L~(-1) while had no impacts on MDA-MB-231 and MDA-MB-468 at 100 μmol·L~(-1).

Identifiants

DOI: 10.19540/j.cnki.cjcmm.20220421.204 PMID: 36046867
pubmed: 36046867
doi: 10.19540/j.cnki.cjcmm.20220421.204
doi:

Substances chimiques

Peptides, Cyclic 0

Types de publication

Journal Article

Langues

chi

Sous-ensembles de citation

IM

Pagination

4391-4394

Auteurs

Xin-Jia Yan (XJ)

Institute of Qinghai-Tibetan Plateau, Southwest Minzu University Chengdu 610041, China Tibetan Plateau Ethnic Medicinal Resources Protection and Utilization Key Laboratory of National Ethnic Affairs Commission of the People's Republic of China Chengdu 610225, China Sichuan Provincial Qiang-Yi Medicinal Resources Protection and Utilization Technology Engineering Laboratory Chengdu 610225, China.

Jing Wen (J)

College of Pharmacy, Harbin University of Commerce Harbin 150076, China.

Yang Song (Y)

Shimadzu (China) Co., Ltd. Shanghai 200233, China.

Dong-Mei Sha (DM)

Institute of Qinghai-Tibetan Plateau, Southwest Minzu University Chengdu 610041, China Tibetan Plateau Ethnic Medicinal Resources Protection and Utilization Key Laboratory of National Ethnic Affairs Commission of the People's Republic of China Chengdu 610225, China Sichuan Provincial Qiang-Yi Medicinal Resources Protection and Utilization Technology Engineering Laboratory Chengdu 610225, China.

Ma-Li-Niu Sha (ML)

Institute of Qinghai-Tibetan Plateau, Southwest Minzu University Chengdu 610041, China Tibetan Plateau Ethnic Medicinal Resources Protection and Utilization Key Laboratory of National Ethnic Affairs Commission of the People's Republic of China Chengdu 610225, China Sichuan Provincial Qiang-Yi Medicinal Resources Protection and Utilization Technology Engineering Laboratory Chengdu 610225, China.

Shao-Shan Zhang (SS)

Institute of Qinghai-Tibetan Plateau, Southwest Minzu University Chengdu 610041, China Tibetan Plateau Ethnic Medicinal Resources Protection and Utilization Key Laboratory of National Ethnic Affairs Commission of the People's Republic of China Chengdu 610225, China Sichuan Provincial Qiang-Yi Medicinal Resources Protection and Utilization Technology Engineering Laboratory Chengdu 610225, China.

Yuan Liu (Y)

Institute of Qinghai-Tibetan Plateau, Southwest Minzu University Chengdu 610041, China Tibetan Plateau Ethnic Medicinal Resources Protection and Utilization Key Laboratory of National Ethnic Affairs Commission of the People's Republic of China Chengdu 610225, China Sichuan Provincial Qiang-Yi Medicinal Resources Protection and Utilization Technology Engineering Laboratory Chengdu 610225, China.

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Classifications MeSH

questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Chromatographie › Chromatographie en phase liquide › Chromatographie en phase liquide à haute performance › [A new cyclopeptide from Selaginella tamariscina].
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectroscopie par résonance magnétique › [A new cyclopeptide from Selaginella tamariscina].
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › [A new cyclopeptide from Selaginella tamariscina].
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Peptides cycliques › [A new cyclopeptide from Selaginella tamariscina].
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Selaginellaceae › [A new cyclopeptide from Selaginella tamariscina].