Mechanisms underlying the methylglyoxal-induced enhancement of uridine diphosphate-mediated contraction in rat femoral artery.
Contraction
Femoral artery
Methylglyoxal
Uridine 5′-diphosphate
p38 mitogen-activated protein kinase
Journal
Journal of pharmacological sciences
ISSN: 1347-8648
Titre abrégé: J Pharmacol Sci
Pays: Japan
ID NLM: 101167001
Informations de publication
Date de publication:
Oct 2022
Oct 2022
Historique:
received:
28
05
2022
revised:
17
07
2022
accepted:
28
07
2022
entrez:
2
9
2022
pubmed:
3
9
2022
medline:
8
9
2022
Statut:
ppublish
Résumé
Although femoral artery dysfunctions, including aberrant vascular reactivity to vasoactive substances, are common in many chronic disorders, such as diabetes and hypertension, their inducible and/or progressive factors remain unclear. Methylglyoxal (MGO), a highly reactive dicarbonyl compound, has been implicated in the pathogenesis of various chronic disorders. However, its direct correlation with extracellular nucleotides including uridine 5'-diphosphate (UDP) in the femoral artery function is currently unknown. Therefore, we investigated the acute effect of MGO on UDP-induced contraction in the rat femoral artery. MGO (4.2 × 10
Identifiants
pubmed: 36055748
pii: S1347-8613(22)00059-7
doi: 10.1016/j.jphs.2022.07.009
pii:
doi:
Substances chimiques
Magnesium Oxide
3A3U0GI71G
Uridine Diphosphate
58-98-0
Pyruvaldehyde
722KLD7415
Syk Kinase
EC 2.7.10.2
p38 Mitogen-Activated Protein Kinases
EC 2.7.11.24
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
100-109Informations de copyright
Copyright © 2022 The Authors. Production and hosting by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest Takayuki Matsumoto, Madoka Yoshioka, Aiko Yamada, Kumiko Taguchi, and Tsuneo Kobayashi all declares that there are no conflicts of interests.