Calcium transients in intramuscular interstitial cells of Cajal of the murine gastric fundus and their regulation by neuroeffector transmission.
Intramuscular ICC (ICC-IM)
calcium biosensor GCaMP6f
gastric motor activity
intracellular Ca2+-transients
neuroeffector motor transmission
Journal
The Journal of physiology
ISSN: 1469-7793
Titre abrégé: J Physiol
Pays: England
ID NLM: 0266262
Informations de publication
Date de publication:
10 2022
10 2022
Historique:
received:
13
05
2022
accepted:
15
08
2022
pubmed:
5
9
2022
medline:
19
10
2022
entrez:
4
9
2022
Statut:
ppublish
Résumé
Enteric neurotransmission is critical for coordinating motility throughout the gastrointestinal (GI) tract. However, there is considerable controversy regarding the cells that are responsible for the transduction of these neural inputs. In the present study, utilization of a cell-specific calcium biosensor GCaMP6f, the spontaneous activity and neuroeffector responses of intramuscular ICC (ICC-IM) to motor neural inputs was examined. Simultaneous intracellular microelectrode recordings and high-speed video-imaging during nerve stimulation was used to reveal the temporal relationship between changes in intracellular Ca
Substances chimiques
Atropine Derivatives
0
Calcium, Dietary
0
Muscarinic Antagonists
0
Nitric Oxide Synthase
EC 1.14.13.39
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4439-4463Informations de copyright
© 2022 The Authors. The Journal of Physiology © 2022 The Physiological Society.
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