Within-host evolution of bacterial pathogens during persistent infection of humans.
Journal
Current opinion in microbiology
ISSN: 1879-0364
Titre abrégé: Curr Opin Microbiol
Pays: England
ID NLM: 9815056
Informations de publication
Date de publication:
12 2022
12 2022
Historique:
received:
09
06
2022
revised:
26
07
2022
accepted:
28
07
2022
pubmed:
6
9
2022
medline:
30
11
2022
entrez:
5
9
2022
Statut:
ppublish
Résumé
Many bacterial pathogens can form persistent infections, providing an infectious reservoir, which allows for infection of new hosts. Currently, the molecular mechanisms and evolutionary dynamics driving persistence are still not well-understood. High-throughput sequencing methods have enabled the study of within-host evolution of persistent bacterial pathogens, revealing common trends among bacterial species in how they adapt to persist. We will focus on trends emerging from longitudinal human-cohort studies, including i) genome-size reduction, ii) metabolic adaptation to the host, iii) antimicrobial resistance, iv) changes in virulence and the bacterial cell surface, and v) hypermutation, and comment on where the field should focus going forward.
Identifiants
pubmed: 36063686
pii: S1369-5274(22)00081-9
doi: 10.1016/j.mib.2022.102197
pii:
doi:
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
102197Informations de copyright
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