Backbone and side chain NMR assignment of the heme-nitric oxide/oxygen binding (H-NOX) domain from Nostoc punctiforme.
H-NOX
NMR spectroscopy
Nostoc punctiforme
Soluble guanylyl cyclase
sGC
Journal
Biomolecular NMR assignments
ISSN: 1874-270X
Titre abrégé: Biomol NMR Assign
Pays: Netherlands
ID NLM: 101472371
Informations de publication
Date de publication:
10 2022
10 2022
Historique:
received:
22
07
2022
accepted:
31
08
2022
pubmed:
7
9
2022
medline:
28
9
2022
entrez:
6
9
2022
Statut:
ppublish
Résumé
Soluble guanylate cyclase (sGC) is considered as the primary NO receptor across several known eukaryotes. The main interest regarding the biological role and its function, focuses on the H-NOX domain of the β1 subunit. This domain in its active form bears a ferrous b type heme as prosthetic group, which facilitates the binding of NO and other diatomic gases. The key point that still needs to be answered is how the protein selectively binds the NO and how the redox state of heme and coordination determines H-NOX active state upon binding of diatomic gases. H-NOX domain is present in the genomes of both prokaryotes and eukaryotes, either as a stand-alone protein domain or as a partner of a larger polypeptide. The biological functions of these signaling modules for a wide range of genomes, diverge considerably along with their ligand binding properties. In this direction, we examine the prokaryotic H-NOX protein domain from Nostoc punctiforme (Npun H-NOX). Herein, we first report the almost complete NMR backbone and side-chain resonance assignment (
Identifiants
pubmed: 36066818
doi: 10.1007/s12104-022-10107-1
pii: 10.1007/s12104-022-10107-1
pmc: PMC9510103
doi:
Substances chimiques
Ligands
0
Receptors, Cytoplasmic and Nuclear
0
Nitric Oxide
31C4KY9ESH
Heme
42VZT0U6YR
Guanylate Cyclase
EC 4.6.1.2
Soluble Guanylyl Cyclase
EC 4.6.1.2
Oxygen
S88TT14065
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
379-384Informations de copyright
© 2022. The Author(s).
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