Antimicrobial Peptide Mechanism Studied by Scattering-Guided Molecular Dynamics Simulation.
Journal
The journal of physical chemistry. B
ISSN: 1520-5207
Titre abrégé: J Phys Chem B
Pays: United States
ID NLM: 101157530
Informations de publication
Date de publication:
15 09 2022
15 09 2022
Historique:
pubmed:
7
9
2022
medline:
17
9
2022
entrez:
6
9
2022
Statut:
ppublish
Résumé
In an effort to combat rising antimicrobial resistance, our labs have rationally designed cationic, helical, amphipathic antimicrobial peptides (AMPs) as alternatives to traditional antibiotics since AMPs incur bacterial resistance in weeks, rather than days. One highly positively charged AMP, WLBU2 (+13
Identifiants
pubmed: 36067064
doi: 10.1021/acs.jpcb.2c03193
pmc: PMC10392866
mid: NIHMS1911732
doi:
Substances chimiques
Antimicrobial Cationic Peptides
0
Antimicrobial Peptides
0
Lipid Bilayers
0
Lipids
0
Phosphates
0
Water
059QF0KO0R
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
6922-6935Subventions
Organisme : NIGMS NIH HHS
ID : P30 GM124166
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI133351
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM123169
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM125917
Pays : United States
Références
Eur Biophys J. 2008 Apr;37(4):421-33
pubmed: 17968536
J Phys Chem B. 2020 Aug 6;124(31):6763-6774
pubmed: 32600036
FEBS Lett. 2000 Oct 6;482(3):265-8
pubmed: 11024473
Annu Rev Microbiol. 1984;38:237-64
pubmed: 6093683
Biophys J. 2007 Feb 1;92(3):903-12
pubmed: 17085495
J Chem Theory Comput. 2014 Feb 11;10(2):676-90
pubmed: 26580045
Antimicrob Agents Chemother. 2005 Aug;49(8):3208-16
pubmed: 16048927
J Antimicrob Chemother. 2007 Sep;60(3):669-72
pubmed: 17623696
Proteins. 2009;77 Suppl 9:89-99
pubmed: 19701941
J Med Chem. 2011 Aug 25;54(16):5786-95
pubmed: 21732630
J Chem Theory Comput. 2019 Jan 8;15(1):775-786
pubmed: 30525595
J Membr Biol. 2010 May;235(1):43-50
pubmed: 20407764
Acc Chem Res. 2016 Jun 21;49(6):1149-57
pubmed: 27188920
Antimicrob Agents Chemother. 2015 Feb;59(2):1329-33
pubmed: 25421473
Faraday Discuss. 2010;144:431-43; discussion 445-81
pubmed: 20158042
J Comput Chem. 2010 Apr 30;31(6):1333-43
pubmed: 20087907
J Chem Theory Comput. 2008 May;4(5):819-34
pubmed: 26621095
Antimicrob Agents Chemother. 2022 Jan 18;66(1):e0144121
pubmed: 34807760
Chemistry. 2020 May 15;26(28):6247-6256
pubmed: 32166806
J Chem Theory Comput. 2020 Mar 10;16(3):1806-1815
pubmed: 32023054
Membranes (Basel). 2015 Sep 22;5(3):473-94
pubmed: 26402709
Proc Natl Acad Sci U S A. 2005 Oct 18;102(42):15059-64
pubmed: 16217012
Sci Adv. 2020 May 01;6(18):eaay6817
pubmed: 32426473
Biochim Biophys Acta. 2009 May;1794(5):808-16
pubmed: 19100346
Biophys J. 1997 May;72(5):2237-42
pubmed: 9129826
Biochim Biophys Acta. 2009 Jul;1788(7):1523-33
pubmed: 19397893
J Phys Condens Matter. 2015 Aug 19;27(32):323103
pubmed: 26194872
Biophys J. 2006 Apr 15;90(8):2796-807
pubmed: 16443652
J Comput Chem. 2017 Jun 5;38(15):1114-1124
pubmed: 27862047
J Chem Phys. 2020 Jul 28;153(4):044130
pubmed: 32752662
Expert Opin Biol Ther. 2014 Jan;14(1):11-4
pubmed: 24206062
Macromol Rapid Commun. 2009 May 19;30(9-10):752-71
pubmed: 21706661
J Comput Chem. 2008 Aug;29(11):1859-65
pubmed: 18351591
Soft Matter. 2019 Feb 20;15(8):1860-1868
pubmed: 30702120
FEBS Lett. 2004 Apr 30;564(3):325-32
pubmed: 15111117
J Phys Chem B. 2018 Mar 1;122(8):2219-2226
pubmed: 29376372
J Antimicrob Chemother. 1999 Jul;44(1):33-41
pubmed: 10459808
J Chem Theory Comput. 2015 Jul 14;11(7):3420-31
pubmed: 26575776
J Phys Chem B. 2010 Sep 2;114(34):11207-20
pubmed: 20695631
ACS Omega. 2018 Dec 31;3(12):17828-17834
pubmed: 30613815
Nat Struct Biol. 1996 Oct;3(10):842-8
pubmed: 8836100
J Chem Theory Comput. 2013 Jan 8;9(1):822-833
pubmed: 23316126
Antimicrob Agents Chemother. 2005 Jan;49(1):316-22
pubmed: 15616311
PLoS One. 2009;4(5):e5453
pubmed: 19434239
J Antimicrob Chemother. 2016 Aug;71(8):2200-7
pubmed: 27231279
Biochim Biophys Acta. 1976 Apr 16;433(1):118-32
pubmed: 769835
Eur Biophys J. 2005 Dec;35(1):53-61
pubmed: 16133633
J Phys Chem B. 2010 Jun 17;114(23):7830-43
pubmed: 20496934
Antimicrob Agents Chemother. 2013 Jun;57(6):2511-21
pubmed: 23507278
Biochim Biophys Acta. 2006 Sep;1758(9):1408-25
pubmed: 16716248
PLoS Biol. 2018 Jan 17;16(1):e2004935
pubmed: 29342145
Interdiscip Sci. 2011 Dec;3(4):272-82
pubmed: 22179761
Phys Chem Chem Phys. 2017 Jul 26;19(29):19289-19299
pubmed: 28702543
Biophys J. 2018 Feb 27;114(4):919-928
pubmed: 29490251
Biochemistry. 2004 Jul 20;43(28):9009-20
pubmed: 15248758
Nat Methods. 2017 Jan;14(1):71-73
pubmed: 27819658
Structure. 2013 Oct 8;21(10):1735-42
pubmed: 24035711
Biochemistry. 2004 May 18;43(19):5608-17
pubmed: 15134435
J Comput Chem. 2014 Oct 15;35(27):1997-2004
pubmed: 25130509
Chem Soc Rev. 2013 Aug 21;42(16):6801-22
pubmed: 23708257
Clin Microbiol Infect. 2018 May;24(5):547.e1-547.e8
pubmed: 28882728