Identification of trypsin-degrading commensals in the large intestine.

Administration, Oral Animals Bacterial Secretion Systems Bacterial Vaccines / administration & dosage Bacteroidetes / isolation & purification COVID-19 / complications Citrobacter rodentium / immunology Diarrhea / complications Feces / microbiology Gastrointestinal Microbiome / genetics Humans Immunoglobulin A / metabolism Intestine, Large / metabolism Mice Murine hepatitis virus / metabolism Proteolysis SARS-CoV-2 / pathogenicity Symbiosis Trypsin / metabolism Virus Internalization

Journal

Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462

Informations de publication

Date de publication:
09 2022
Historique:
received: 01 08 2021
accepted: 02 08 2022
pubmed: 8 9 2022
medline: 20 9 2022
entrez: 7 9 2022
Statut: ppublish

Résumé

Increased levels of proteases, such as trypsin, in the distal intestine have been implicated in intestinal pathological conditions

Identifiants

DOI: 10.1038/s41586-022-05181-3 PMID: 36071157 PMC: PMC9477747
pubmed: 36071157
doi: 10.1038/s41586-022-05181-3
pii: 10.1038/s41586-022-05181-3
pmc: PMC9477747
doi:

Substances chimiques

Bacterial Secretion Systems 0
Bacterial Vaccines 0
Immunoglobulin A 0
Trypsin EC 3.4.21.4

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

582-589

Subventions

Organisme : NIDDK NIH HHS
ID : P30 DK043351
Pays : United States
Organisme : NCCIH NIH HHS
ID : R01 AT009708
Pays : United States

Informations de copyright

© 2022. The Author(s).

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Auteurs

Youxian Li (Y)

RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan.
Institute for Cancer Research, Faculty of Medicine, University of Oslo, Oslo, Norway.

Eiichiro Watanabe (E)

RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan.
Department of Pediatric Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.
ORCID: 0000-0003-2050-3740

Yusuke Kawashima (Y)

RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Department of Applied Genomics, Kazusa DNA Research Institute, Kisarazu, Japan.
ORCID: 0000-0002-9779-8199

Damian R Plichta (DR)

Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
ORCID: 0000-0002-6555-2557

Zhujun Wang (Z)

RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan.

Makoto Ujike (M)

Faculty of Veterinary Medicine, Nippon Veterinary and Life Science University, Tokyo, Japan.
ORCID: 0000-0002-7145-7126

Qi Yan Ang (QY)

Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
ORCID: 0000-0002-9788-1283

Runrun Wu (R)

Interdisciplinary Life Science-PULSe, Purdue University, West Lafayette, IN, USA.

Munehiro Furuichi (M)

Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan.
ORCID: 0000-0001-7742-1135

Kozue Takeshita (K)

Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan.

Koji Yoshida (K)

Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan.
ORCID: 0000-0002-0466-8994

Keita Nishiyama (K)

Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan.

Sean M Kearney (SM)

Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan.

Wataru Suda (W)

RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.

Masahira Hattori (M)

RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Cooperative Major in Advanced Health Science, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo, Japan.

Satoshi Sasajima (S)

Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan.

Takahiro Matsunaga (T)

RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.

Xiaoxi Zhang (X)

RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan.

Kazuto Watanabe (K)

JSR-Keio University Medical and Chemical Innovation Center, Keio University School of Medicine, Tokyo, Japan.

Jun Fujishiro (J)

Department of Pediatric Surgery, Faculty of Medicine, The University of Tokyo, Tokyo, Japan.

Jason M Norman (JM)

Vedanta Biosciences, Cambridge, MA, USA.
ORCID: 0000-0001-5049-8415

Bernat Olle (B)

Vedanta Biosciences, Cambridge, MA, USA.

Shutoku Matsuyama (S)

Department of Virology III, National Institute of Infectious Diseases, Tokyo, Japan.

Ho Namkoong (H)

Department of Infectious Diseases, Keio University School of Medicine, Tokyo, Japan.

Yoshifumi Uwamino (Y)

Department of Laboratory Medicine, Keio University School of Medicine, Tokyo, Japan.

Makoto Ishii (M)

Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.

Koichi Fukunaga (K)

Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan.

Naoki Hasegawa (N)

Department of Infectious Diseases, Keio University School of Medicine, Tokyo, Japan.
ORCID: 0000-0003-0717-7450

Osamu Ohara (O)

RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.
Department of Applied Genomics, Kazusa DNA Research Institute, Kisarazu, Japan.
ORCID: 0000-0002-3328-9571

Ramnik J Xavier (RJ)

Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA, USA. xavier@molbio.mgh.harvard.edu.
Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA. xavier@molbio.mgh.harvard.edu.
Center for Computational and Integrative Biology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. xavier@molbio.mgh.harvard.edu.
ORCID: 0000-0002-5630-5167

Koji Atarashi (K)

RIKEN Center for Integrative Medical Sciences, Yokohama, Japan. kojiatarashi@keio.jp.
Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan. kojiatarashi@keio.jp.
JSR-Keio University Medical and Chemical Innovation Center, Keio University School of Medicine, Tokyo, Japan. kojiatarashi@keio.jp.
ORCID: 0000-0001-5422-0736

Kenya Honda (K)

RIKEN Center for Integrative Medical Sciences, Yokohama, Japan. kenya@keio.jp.
Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo, Japan. kenya@keio.jp.
JSR-Keio University Medical and Chemical Innovation Center, Keio University School of Medicine, Tokyo, Japan. kenya@keio.jp.
ORCID: 0000-0001-8937-9835

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Classifications MeSH

questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Voies d'administration de substances chimiques et des médicaments › Administration par voie orale › Identification of trypsin-degrading commensals...
questionsmedicales.fr › Eucaryotes › Animaux › Identification of trypsin-degrading commensals...
questionsmedicales.fr › Structures macromoléculaires › Complexes multiprotéiques › Systèmes de translocation des protéines › Systèmes bactériens de sécrétion › Identification of trypsin-degrading commensals...
questionsmedicales.fr › Mélanges complexes › Produits biologiques › Vaccins › Vaccins antibactériens › Identification of trypsin-degrading commensals...
questionsmedicales.fr › Bactéries › Bactéries à Gram négatif › Bacteroidetes › Identification of trypsin-degrading commensals...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Identification of trypsin-degrading commensals...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Citrobacter › Citrobacter rodentium › Identification of trypsin-degrading commensals...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Signes et symptômes digestifs › Diarrhée › Identification of trypsin-degrading commensals...
questionsmedicales.fr › Liquides et sécrétions biologiques › Fèces › Identification of trypsin-degrading commensals...
questionsmedicales.fr › Environnement et santé publique › Environnement › Écosystème › Biodiversité › Biote › Microbiote › Microbiome gastro-intestinal › Identification of trypsin-degrading commensals...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Identification of trypsin-degrading commensals...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Isotypes des immunoglobulines › Immunoglobuline A › Identification of trypsin-degrading commensals...
questionsmedicales.fr › Système digestif › Tube digestif › Tube digestif inférieur › Gros intestin › Identification of trypsin-degrading commensals...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Identification of trypsin-degrading commensals...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus de l'hépatite murine › Identification of trypsin-degrading commensals...
questionsmedicales.fr › Métabolisme › Protéolyse › Identification of trypsin-degrading commensals...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › Identification of trypsin-degrading commensals...
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questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Peptide hydrolases › Protéases à sérine › Serine endopeptidases › Trypsine › Identification of trypsin-degrading commensals...
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