Venglustat Inhibits Protein N-Terminal Methyltransferase 1 in a Substrate-Competitive Manner.
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
22 09 2022
22 09 2022
Historique:
pubmed:
9
9
2022
medline:
24
9
2022
entrez:
8
9
2022
Statut:
ppublish
Résumé
Venglustat is a known allosteric inhibitor for ceramide glycosyltransferase, investigated in diseases caused by lysosomal dysfunction. Here, we identified venglustat as a potent inhibitor (IC
Identifiants
pubmed: 36074125
doi: 10.1021/acs.jmedchem.2c01050
pmc: PMC9813856
mid: NIHMS1859204
doi:
Substances chimiques
Carbamates
0
Ceramides
0
Enzyme Inhibitors
0
Quinuclidines
0
venglustat
BLP1XA3FZA
Methyltransferases
EC 2.1.1.-
Glycosyltransferases
EC 2.4.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
12334-12345Subventions
Organisme : NCI NIH HHS
ID : P30 CA023168
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA214649
Pays : United States
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