The human disease gene LYSET is essential for lysosomal enzyme transport and viral infection.
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
07 10 2022
07 10 2022
Historique:
pubmed:
9
9
2022
medline:
12
10
2022
entrez:
8
9
2022
Statut:
ppublish
Résumé
Lysosomes are key degradative compartments of the cell. Transport to lysosomes relies on GlcNAc-1-phosphotransferase-mediated tagging of soluble enzymes with mannose 6-phosphate (M6P). GlcNAc-1-phosphotransferase deficiency leads to the severe lysosomal storage disorder mucolipidosis II (MLII). Several viruses require lysosomal cathepsins to cleave structural proteins and thus depend on functional GlcNAc-1-phosphotransferase. We used genome-scale CRISPR screens to identify lysosomal enzyme trafficking factor (LYSET, also named TMEM251) as essential for infection by cathepsin-dependent viruses including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). LYSET deficiency resulted in global loss of M6P tagging and mislocalization of GlcNAc-1-phosphotransferase from the Golgi complex to lysosomes.
Identifiants
pubmed: 36074821
doi: 10.1126/science.abn5648
pmc: PMC9547973
mid: NIHMS1836118
doi:
Substances chimiques
LYSET protein, human
0
Proteins
0
Transferases (Other Substituted Phosphate Groups)
EC 2.7.8.-
Cathepsins
EC 3.4.-
Mannose
PHA4727WTP
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
eabn5648Subventions
Organisme : NCI NIH HHS
ID : K00 CA212454
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI141970
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM058867
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007276
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI130123
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI140186
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007502
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI134907
Pays : United States
Références
Hum Mutat. 2021 Jan;42(1):89-101
pubmed: 33252156
Nature. 2022 Mar;603(7902):706-714
pubmed: 35104837
Nat Protoc. 2007;2(10):2480-91
pubmed: 17947990
Nat Med. 2005 Oct;11(10):1109-12
pubmed: 16200072
Hum Mutat. 2020 Jul;41(7):1321-1328
pubmed: 32220096
Anal Chem. 2014 Jun 3;86(11):5478-86
pubmed: 24796651
Biochim Biophys Acta. 2009 Apr;1793(4):605-14
pubmed: 19046998
Proteomes. 2021 Jan 26;9(1):
pubmed: 33530589
Development. 2001 Dec;128(23):4899-910
pubmed: 11731469
J Proteome Res. 2018 Sep 7;17(9):2917-2924
pubmed: 30114372
Traffic. 2015 Jul;16(7):743-59
pubmed: 25786328
Cell Host Microbe. 2020 Sep 9;28(3):486-496.e6
pubmed: 32738193
J Proteome Res. 2020 Aug 7;19(8):3286-3301
pubmed: 32500713
Nat Microbiol. 2019 Dec;4(12):2523-2537
pubmed: 31527793
Nature. 2011 Aug 24;477(7364):340-3
pubmed: 21866103
Science. 2011 Jul 1;333(6038):87-90
pubmed: 21719679
Annu Rev Biochem. 2010;79:803-33
pubmed: 20196649
Anal Chem. 2019 Aug 20;91(16):10401-10406
pubmed: 31287300
Methods Enzymol. 2018;598:217-235
pubmed: 29306436
Cell. 2021 Jan 7;184(1):106-119.e14
pubmed: 33333024
Int J Mol Sci. 2020 Sep 17;21(18):
pubmed: 32957425
Curr Protoc Bioinformatics. 2012 Dec;Chapter 13:Unit13.20
pubmed: 23255153
Nat Commun. 2020 Nov 18;11(1):5885
pubmed: 33208793
Nat Biotechnol. 2016 Feb;34(2):184-191
pubmed: 26780180
Nature. 2020 May;581(7809):434-443
pubmed: 32461654
J Am Chem Soc. 2013 Oct 2;135(39):14726-30
pubmed: 23971698
Mol Cell Proteomics. 2019 Jan;18(1):16-27
pubmed: 30237200
Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14764-9
pubmed: 9405687
Nature. 2003 Nov 27;426(6965):450-4
pubmed: 14647384
Sci Data. 2020 Feb 26;7(1):68
pubmed: 32103020
Nat Biotechnol. 2008 Dec;26(12):1367-72
pubmed: 19029910
DNA Cell Biol. 2012 Dec;31(12):1646-9
pubmed: 23134451
Genome Res. 2014 Dec;24(12):2059-65
pubmed: 25373145
J Virol. 2010 Jan;84(1):163-75
pubmed: 19846533
Proc Natl Acad Sci U S A. 2005 Aug 16;102(33):11876-81
pubmed: 16081529
Nucleic Acids Res. 2019 Jan 8;47(D1):D506-D515
pubmed: 30395287
Mol Cell Proteomics. 2017 Jul;16(7):1173-1187
pubmed: 28539326
Biol Chem. 2002 May;383(5):751-6
pubmed: 12108539
J Clin Invest. 2000 Mar;105(5):673-81
pubmed: 10712439
Science. 1967 Aug 18;157(3790):804-6
pubmed: 17842782
Genome Biol. 2014;15(12):554
pubmed: 25476604
Nat Biotechnol. 2016 Nov;34(11):1198-1205
pubmed: 27748755
PLoS One. 2009 Aug 06;4(8):e6529
pubmed: 19657394
J Biol Chem. 2013 Jan 11;288(2):1238-49
pubmed: 23192343
Science. 2005 Jun 10;308(5728):1643-5
pubmed: 15831716
J Proteome Res. 2012 Sep 7;11(9):4517-25
pubmed: 22800195
Cell Host Microbe. 2020 May 13;27(5):841-848.e3
pubmed: 32289263
Invest Ophthalmol Vis Sci. 2007 Nov;48(11):5221-8
pubmed: 17962477
Eur J Cell Biol. 1992 Apr;57(2):184-92
pubmed: 1387363
Nat Methods. 2014 Aug;11(8):783-784
pubmed: 25075903
Hum Mutat. 2014 Mar;35(3):368-76
pubmed: 24375680
Glycobiology. 2001 Aug;11(8):633-44
pubmed: 11479274
J Virol. 2013 Dec;87(23):12552-61
pubmed: 24027332
Bioinformatics. 2010 Apr 1;26(7):966-8
pubmed: 20147306
Proc Natl Acad Sci U S A. 2014 Mar 4;111(9):3532-7
pubmed: 24550498
Curr Protoc Cell Biol. 2015 Dec 01;69:3.1.1-3.1.22
pubmed: 26621372
Mass Spectrom Rev. 2020 May;39(3):229-244
pubmed: 28691345
J Biol Chem. 2002 Jul 5;277(27):24609-17
pubmed: 11986312
Anal Biochem. 1986 May 1;154(2):655-63
pubmed: 3728974
J Microsc. 2006 Dec;224(Pt 3):213-32
pubmed: 17210054
Nucleic Acids Res. 2019 Jan 8;47(D1):D419-D426
pubmed: 30407594
Nature. 2022 Mar;603(7902):715-720
pubmed: 35104836
Nat Protoc. 2013 Nov;8(11):2281-2308
pubmed: 24157548
Am J Pathol. 2010 Jul;177(1):240-7
pubmed: 20472886
Mol Biol Cell. 2011 Apr 15;22(8):1135-47
pubmed: 21325625
Nat Methods. 2016 Sep;13(9):731-40
pubmed: 27348712
Cell. 2020 Apr 16;181(2):271-280.e8
pubmed: 32142651
Int J Proteomics. 2012;2012:560391
pubmed: 22701174