Pleiotropic Ankyrins: Scaffolds for Ion Channels and Transporters.
Ankyrin
Ankyrin-B
Ankyrin-G
Ankyrin-R
calcium channels
exchange proteins
ion channels
potassium channels
pumps
scaffold
sodium channels
transporters
Journal
Channels (Austin, Tex.)
ISSN: 1933-6969
Titre abrégé: Channels (Austin)
Pays: United States
ID NLM: 101321614
Informations de publication
Date de publication:
12 2022
12 2022
Historique:
entrez:
9
9
2022
pubmed:
10
9
2022
medline:
14
9
2022
Statut:
ppublish
Résumé
The ankyrin proteins (Ankyrin-R, Ankyrin-B, and Ankyrin-G) are a family of scaffolding, or membrane adaptor proteins necessary for the regulation and targeting of several types of ion channels and membrane transporters throughout the body. These include voltage-gated sodium, potassium, and calcium channels in the nervous system, heart, lungs, and muscle. At these sites, ankyrins recruit ion channels, and other membrane proteins, to specific subcellular domains, which are then stabilized through ankyrin's interaction with the submembranous spectrin-based cytoskeleton. Several recent studies have expanded our understanding of both ankyrin expression and their ion channel binding partners. This review provides an updated overview of ankyrin proteins and their known channel and transporter interactions. We further discuss several potential avenues of future research that would expand our understanding of these important organizational proteins.
Identifiants
pubmed: 36082411
doi: 10.1080/19336950.2022.2120467
pmc: PMC9467607
doi:
Substances chimiques
Ankyrins
0
Ion Channels
0
Membrane Proteins
0
Spectrin
12634-43-4
Types de publication
Journal Article
Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
216-229Subventions
Organisme : NINDS NIH HHS
ID : R35 NS122073
Pays : United States
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