Ionic Strength and Solution Composition Dictate the Adsorption of Cell-Penetrating Peptides onto Phosphatidylcholine Membranes.


Journal

Langmuir : the ACS journal of surfaces and colloids
ISSN: 1520-5827
Titre abrégé: Langmuir
Pays: United States
ID NLM: 9882736

Informations de publication

Date de publication:
20 09 2022
Historique:
pubmed: 10 9 2022
medline: 23 9 2022
entrez: 9 9 2022
Statut: ppublish

Résumé

Adsorption of arginine-rich positively charged peptides onto neutral zwitterionic phosphocholine (PC) bilayers is a key step in the translocation of those potent cell-penetrating peptides into the cell interior. In the past, we have shown both theoretically and experimentally that polyarginines adsorb to the neutral PC-supported lipid bilayers in contrast to polylysines. However, comparing our results with previous studies showed that the results often do not match even at the qualitative level. The adsorption of arginine-rich peptides onto 1-palmitoyl-2-oleoyl-

Identifiants

pubmed: 36083171
doi: 10.1021/acs.langmuir.2c01435
pmc: PMC9494944
doi:

Substances chimiques

Cell-Penetrating Peptides 0
Lecithins 0
Lipid Bilayers 0
Phosphatidylcholines 0
Phosphorylcholine 107-73-3
Arginine 94ZLA3W45F

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

11284-11295

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Auteurs

Man Thi Hong Nguyen (MTH)

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo nám. 542/2, CZ-16000 Prague 6, Czech Republic.

Denys Biriukov (D)

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo nám. 542/2, CZ-16000 Prague 6, Czech Republic.

Carmelo Tempra (C)

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo nám. 542/2, CZ-16000 Prague 6, Czech Republic.

Katarina Baxova (K)

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo nám. 542/2, CZ-16000 Prague 6, Czech Republic.

Hector Martinez-Seara (H)

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo nám. 542/2, CZ-16000 Prague 6, Czech Republic.

Hüseyin Evci (H)

J. Heyrovský Institute of Physical Chemistry of the Czech Academy of Sciences, Dolejškova 2155/3, CZ-18223 Prague 8, Czech Republic.
Department of Chemistry, Faculty of Science, University of South Bohemia in Ceske Budejovice, 370 05 Ceske Budejovice, Czech Republic.

Vandana Singh (V)

J. Heyrovský Institute of Physical Chemistry of the Czech Academy of Sciences, Dolejškova 2155/3, CZ-18223 Prague 8, Czech Republic.
Faculty of Mathematics and Physics at Charles University, 110 00 Prague, Czech Republic.

Radek Šachl (R)

J. Heyrovský Institute of Physical Chemistry of the Czech Academy of Sciences, Dolejškova 2155/3, CZ-18223 Prague 8, Czech Republic.

Martin Hof (M)

J. Heyrovský Institute of Physical Chemistry of the Czech Academy of Sciences, Dolejškova 2155/3, CZ-18223 Prague 8, Czech Republic.

Pavel Jungwirth (P)

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo nám. 542/2, CZ-16000 Prague 6, Czech Republic.

Matti Javanainen (M)

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo nám. 542/2, CZ-16000 Prague 6, Czech Republic.
Institute of Biotechnology, University of Helsinki, FI-00014 University of Helsinki, Finland.

Mario Vazdar (M)

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Flemingovo nám. 542/2, CZ-16000 Prague 6, Czech Republic.
Department of Mathematics, University of Chemistry and Technology, 166 28 Prague, Czech Republic.

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Classifications MeSH