Artificial pore blocker acts specifically on voltage-gated potassium channel isoform K

Potassium Channels, Voltage-Gated / genetics Amino Acid Sequence Potassium Channel Blockers / chemistry Peptides / chemistry Ligands Protein Isoforms / genetics Kv1.3 Potassium Channel / genetics Kv1.1 Potassium Channel / metabolism Kv1.2 Potassium Channel / metabolism Kv1.5 Potassium Channel / metabolism
NMR molecular dynamics molecular modeling protein design protein structure voltage-gated potassium channel α-hairpinin

Journal

The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R

Informations de publication

Date de publication:
11 2022
Historique:
received: 07 02 2022
revised: 31 08 2022
accepted: 03 09 2022
pubmed: 11 9 2022
medline: 30 11 2022
entrez: 10 9 2022
Statut: ppublish

Résumé

Among voltage-gated potassium channel (K

Identifiants

DOI: 10.1016/j.jbc.2022.102467 PMID: 36087839 PMC: PMC9637586
pubmed: 36087839
pii: S0021-9258(22)00910-3
doi: 10.1016/j.jbc.2022.102467
pmc: PMC9637586
pii:
doi:

Substances chimiques

Potassium Channels, Voltage-Gated 0
Potassium Channel Blockers 0
Peptides 0
Ligands 0
Protein Isoforms 0
Kv1.3 Potassium Channel 0
Kv1.1 Potassium Channel 147173-20-4
Kv1.2 Potassium Channel 0
Kv1.5 Potassium Channel 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

102467

Informations de copyright

Copyright © 2022 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Conflict of interest The authors declare that they have no conflicts of interest with the contents of this article.

Auteurs

Andrei M Gigolaev (AM)

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.

Vladislav A Lushpa (VA)

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia; Moscow Institute of Physics and Technology, State University, Moscow Region, Russia.

Ernesto L Pinheiro-Junior (EL)

Toxicology and Pharmacology, University of Leuven, Leuven, Belgium.

Valentin M Tabakmakher (VM)

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia; Institute of Life Sciences and Biomedicine, Far Eastern Federal University, Vladivostok, Russia.

Steve Peigneur (S)

Toxicology and Pharmacology, University of Leuven, Leuven, Belgium.

Anastasija A Ignatova (AA)

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.

Alexey V Feofanov (AV)

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.

Roman G Efremov (RG)

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia.

Konstantin S Mineev (KS)

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia; Moscow Institute of Physics and Technology, State University, Moscow Region, Russia.

Jan Tytgat (J)

Toxicology and Pharmacology, University of Leuven, Leuven, Belgium.

Alexander A Vassilevski (AA)

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia; Moscow Institute of Physics and Technology, State University, Moscow Region, Russia. Electronic address: avas@ibch.ru.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux potassiques › Canaux potassiques voltage-dépendants › Artificial pore blocker acts specifically on...
questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Données de séquences moléculaires › Séquence d'acides aminés › Artificial pore blocker acts specifically on...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents cardiovasculaires › Inhibiteurs des canaux potassiques › Artificial pore blocker acts specifically on...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Artificial pore blocker acts specifically on...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › Artificial pore blocker acts specifically on...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Isoformes de protéines › Artificial pore blocker acts specifically on...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux potassiques › Canaux potassiques voltage-dépendants › Canaux potassiques de la superfamille Shaker › Canal potassique Kv1.3 › Artificial pore blocker acts specifically on...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux potassiques › Canaux potassiques voltage-dépendants › Canaux potassiques de la superfamille Shaker › Canal potassique Kv1.1 › Artificial pore blocker acts specifically on...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux potassiques › Canaux potassiques voltage-dépendants › Canaux potassiques de la superfamille Shaker › Canal potassique Kv1.2 › Artificial pore blocker acts specifically on...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux potassiques › Canaux potassiques voltage-dépendants › Canaux potassiques de la superfamille Shaker › Canal potassique Kv1.5 › Artificial pore blocker acts specifically on...