The deficiency in Th2-like Tfh cells affects the maturation and quality of HIV-specific B cell response in viremic infection.
HIV-1 infection
T helper cell
follicular T helper cells
germinal center B cells (GC B cells)
lymph nodes
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2022
2022
Historique:
received:
02
06
2022
accepted:
05
08
2022
entrez:
12
9
2022
pubmed:
13
9
2022
medline:
14
9
2022
Statut:
epublish
Résumé
Optimal T follicular helper (Tfh) cells function is important to promote the development of germinal centers and maturation of high affinity antigen-specific B cells. We have found that the expression of CXCR3 defines distinct Tfh subsets: CXCR3
Identifiants
pubmed: 36091040
doi: 10.3389/fimmu.2022.960120
pmc: PMC9450063
doi:
Substances chimiques
Cytokines
0
Interleukin-4
207137-56-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
960120Informations de copyright
Copyright © 2022 Noto, Suffiotti, Joo, Mancarella, Procopio, Cavet, Leung, Corpataux, Cavassini, Riva, Stamatatos, Gottardo, McDermott, Koup, Fenwick, Perreau and Pantaleo.
Déclaration de conflit d'intérêts
GC and YL were employed by the company Atreca, Inc. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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