Physiological, Biochemical, and Structural Bioinformatic Analysis of the Multiple Inositol Dehydrogenases from Corynebacterium glutamicum.

Corynebacterium glutamicum d-chiro-inositol enzyme kinetics inositol dehydrogenase inositol metabolism inositols molecular docking myo-inositol scyllo-inositol structural models

Journal

Microbiology spectrum
ISSN: 2165-0497
Titre abrégé: Microbiol Spectr
Pays: United States
ID NLM: 101634614

Informations de publication

Date de publication:
26 10 2022
Historique:
pubmed: 13 9 2022
medline: 29 10 2022
entrez: 12 9 2022
Statut: ppublish

Résumé

Inositols (cyclohexanehexols) comprise nine isomeric cyclic sugar alcohols, several of which occur in all domains of life with various functions. Many bacteria can utilize inositols as carbon and energy sources via a specific pathway involving inositol dehydrogenases (IDHs) as the first step of catabolism. The microbial cell factory Corynebacterium glutamicum can grow with

Identifiants

pubmed: 36094194
doi: 10.1128/spectrum.01950-22
pmc: PMC9603128
doi:

Substances chimiques

Carbon 7440-44-0
Inositol 4L6452S749
NAD 0U46U6E8UK
Oxidoreductases EC 1.-
scyllitol 1VS4X81277
Soil 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e0195022

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Auteurs

Paul Ramp (P)

IBG-1: Biotechnology, Institute of Bio- and Geosciences, Forschungszentrum Jülichgrid.8385.6, Jülich, Germany.
The Bioeconomy Science Center (BioSC), Forschungszentrum Jülichgrid.8385.6, Jülich, Germany.

Christopher Pfleger (C)

Institut für Pharmazeutische und Medizinische Chemie, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany.

Jonas Dittrich (J)

The Bioeconomy Science Center (BioSC), Forschungszentrum Jülichgrid.8385.6, Jülich, Germany.
Institut für Pharmazeutische und Medizinische Chemie, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany.

Christina Mack (C)

IBG-1: Biotechnology, Institute of Bio- and Geosciences, Forschungszentrum Jülichgrid.8385.6, Jülich, Germany.

Holger Gohlke (H)

The Bioeconomy Science Center (BioSC), Forschungszentrum Jülichgrid.8385.6, Jülich, Germany.
Institut für Pharmazeutische und Medizinische Chemie, Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany.
John von Neumann Institute for Computing (NIC), Forschungszentrum Jülichgrid.8385.6 GmbH, Jülich, Germany.
Jülich Supercomputing Centre (JSC), Forschungszentrum Jülichgrid.8385.6 GmbH, Jülich, Germany.
Institute of Biological Information Processing (IBI-7: Structural Biochemistry), Forschungszentrum Jülichgrid.8385.6 GmbH, Jülich, Germany.
Institute of Bio- and Geosciences (IBG-4: Bioinformatics), Forschungszentrum Jülichgrid.8385.6 GmbH, Jülich, Germany.

Michael Bott (M)

IBG-1: Biotechnology, Institute of Bio- and Geosciences, Forschungszentrum Jülichgrid.8385.6, Jülich, Germany.
The Bioeconomy Science Center (BioSC), Forschungszentrum Jülichgrid.8385.6, Jülich, Germany.

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Classifications MeSH