Role of syndecan-4 in breast cancer pathophysiology.

Humans Female Syndecan-4 / genetics Heparan Sulfate Proteoglycans / metabolism Breast Neoplasms / pathology Zoledronic Acid Progesterone Ligands Receptors, Estrogen Extracellular Matrix Proteins MicroRNAs Intercellular Signaling Peptides and Proteins Trastuzumab Integrins Estrogens Syndecan-1 Tumor Microenvironment
breast cancer heparan sulfate proteoglycan microRNA syndecan-4 therapy

Journal

American journal of physiology. Cell physiology
ISSN: 1522-1563
Titre abrégé: Am J Physiol Cell Physiol
Pays: United States
ID NLM: 100901225

Informations de publication

Date de publication:
01 11 2022
Historique:
pubmed: 13 9 2022
medline: 22 10 2022
entrez: 12 9 2022
Statut: ppublish

Résumé

Expression of the cell surface heparan sulfate proteoglycan syndecan-4 is dysregulated in breast cancer, the most frequent malignancy in women. High expression of syndecan-4 correlates with a worse survival in the subgroup of estrogen receptor negative and estrogen/progesterone-receptor negative patients. Aberrant expression of syndecan-4 in breast cancer involves both transcriptional and posttranscriptional mechanisms, including estrogen- and growth factor-dependent regulation, mutations in

Identifiants

DOI: 10.1152/ajpcell.00152.2022 PMID: 36094435
pubmed: 36094435
doi: 10.1152/ajpcell.00152.2022
doi:

Substances chimiques

Syndecan-4 0
Heparan Sulfate Proteoglycans 0
Zoledronic Acid 6XC1PAD3KF
Progesterone 4G7DS2Q64Y
Ligands 0
Receptors, Estrogen 0
Extracellular Matrix Proteins 0
MicroRNAs 0
Intercellular Signaling Peptides and Proteins 0
Trastuzumab P188ANX8CK
Integrins 0
Estrogens 0
Syndecan-1 0
NUP153 protein, human 0

Types de publication

Journal Article Review Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

C1345-C1354

Auteurs

Jessica Oyie Sousa Onyeisi (JOS)

Department of Gynecology and Obstetrics, Münster University Hospital, Munster, Germany.
Disciplina de Biologia Molecular, Departamento de Bioquímica, Universidade Federal de São Paulo, Sao Paulo, Brazil.

Carla Cristina Lopes (CC)

Disciplina de Biologia Molecular, Departamento de Bioquímica, Universidade Federal de São Paulo, Sao Paulo, Brazil.
Departamento de Ciências Biológicas, Instituto de Ciências Ambientais, Químicas e Farmacêuticas, Universidade Federal de São Paulo, Sao Paulo, Brazil.

Martin Götte (M)

Department of Gynecology and Obstetrics, Münster University Hospital, Munster, Germany.
ORCID: 0000-0003-2360-2496

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Role of syndecan-4 in breast cancer pathophysiology.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Glycoprotéines membranaires › Syndécanes › Syndécane-4 › Role of syndecan-4 in breast cancer pathophysiology.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Glycoprotéines › Protéoglycanes › Protéoglycanes à sulfate d'héparane › Role of syndecan-4 in breast cancer pathophysiology.
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › Role of syndecan-4 in breast cancer pathophysiology.
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Imidazoles › Acide zolédronique › Role of syndecan-4 in breast cancer pathophysiology.
questionsmedicales.fr › Hormones gonadiques › Hormones sexuelles stéroïdiennes › Congénères de la progestérone › Progestérone › Role of syndecan-4 in breast cancer pathophysiology.
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands › Role of syndecan-4 in breast cancer pathophysiology.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Récepteurs aux stéroïdes › Récepteurs des oestrogènes › Role of syndecan-4 in breast cancer pathophysiology.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Scléroprotéines › Protéines de la matrice extracellulaire › Role of syndecan-4 in breast cancer pathophysiology.
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › microARN › Role of syndecan-4 in breast cancer pathophysiology.
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Role of syndecan-4 in breast cancer pathophysiology.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Anticorps monoclonaux › Anticorps monoclonaux humanisés › Trastuzumab › Role of syndecan-4 in breast cancer pathophysiology.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Intégrines › Role of syndecan-4 in breast cancer pathophysiology.
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hormones, substituts d'hormones et antagonistes d'hormones › Hormones › Oestrogènes › Role of syndecan-4 in breast cancer pathophysiology.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Glycoprotéines membranaires › Syndécanes › Syndécane-1 › Role of syndecan-4 in breast cancer pathophysiology.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Microenvironnement cellulaire › Microenvironnement tumoral › Role of syndecan-4 in breast cancer pathophysiology.