Conjugation of the ubiquitin family proteins to phospholipids.
Atg8
endosome
phosphatidylethanolamine
phospholipids
ubiquitin
ubiquitin-like proteins
Journal
Autophagy
ISSN: 1554-8635
Titre abrégé: Autophagy
Pays: United States
ID NLM: 101265188
Informations de publication
Date de publication:
04 2023
04 2023
Historique:
pubmed:
13
9
2022
medline:
14
3
2023
entrez:
12
9
2022
Statut:
ppublish
Résumé
Conjugation of Atg8-family proteins to phosphatidylethanolamine (PE) is important for autophagosome formation. PE conjugation has been thought to be specific to Atg8 among the ubiquitin-family proteins. However, this dogma has not been experimentally verified. Our recent study revealed that ubiquitin is also conjugated to PE on endosomes and the vacuole (or lysosomes). Other ubiquitin-like proteins, such as NEDD8 and ISG15, also covalently bind to phospholipids. We propose that conjugation to phospholipids could be a common feature of the ubiquitin family.
Identifiants
pubmed: 36095076
doi: 10.1080/15548627.2022.2123637
pmc: PMC10012920
doi:
Substances chimiques
Phospholipids
0
Saccharomyces cerevisiae Proteins
0
Autophagy-Related Protein 8 Family
0
Ubiquitins
0
Ubiquitin
0
Microtubule-Associated Proteins
0
Autophagy-Related Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1361-1362Références
Mol Cell. 2022 Oct 6;82(19):3677-3692.e11
pubmed: 36044902